Evidence map›Paper›PMID 33022221›Full record

ArticleAmerican journal of human genetics2020

Breast Cancer Polygenic Risk Score and Contralateral Breast Cancer Risk.

Iris Kramer, Maartje J Hooning, Nasim Mavaddat, Michael Hauptmann, Renske Keeman, Ewout W Steyerberg, Daniele Giardiello, Antonis C Antoniou, Paul D P Pharoah, Sander Canisius and 133 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 3 pooled it
6.8field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 3 syntheses or guidelines pooled it, 64 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
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  8. [Application of polygenic risk score-based comprehensive breast cancer risk assessment in preimplantation embryo selection for aZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Breast Cancer Polygenic Risk Score Associated with Outcomes after In Situ Breast Disease.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

143 authors at 20 institutions in 26 countries.

Iris KramerThe Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam 1066 CX, the Netherlands.
Maartje J HooningErasmus MC Cancer Institute, Department of Medical Oncology, Rotterdam 3015 CN, the Netherlands.
Nasim MavaddatUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge CB1 8RN, UK.
Michael HauptmannThe Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Department of Epidemiology and Biostatistics, Amsterdam 1066 CX, the Netherlands; Brandenburg Medical School Theodor Fontane, Institute of Biostatistics and Registry Research, Neuruppin 16816, Germany.
Renske KeemanThe Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam 1066 CX, the Netherlands.
Ewout W SteyerbergLeiden University Medical Center, Department of Biomedical Data Sciences, Leiden 2333 ZA, the Netherlands; Erasmus MC, Department of Public Health, Rotterdam 3015 GD, the Netherlands.
Daniele GiardielloThe Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam 1066 CX, the Netherlands; Leiden University Medical Center, Department of Biomedical Data Sciences, Leiden 2333 ZA, the Netherlands.
Antonis C AntoniouUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge CB1 8RN, UK.
Paul D P PharoahUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge CB1 8RN, UK; University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge CB1 8RN, UK.
Sander CanisiusThe Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam 1066 CX, the Netherlands; The Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Division of Molecular Carcinogenesis, Amsterdam 1066 CX, the Netherlands.
Zumuruda Abu-FulCarmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa 35254, Israel.
Irene L AndrulisLunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Fred A. Litwin Center for Cancer Genetics, Toronto, ON M5G 1X5, Canada; University of Toronto, Department of Molecular Genetics, Toronto, ON M5S 1A8, Canada.
Hoda Anton-CulverUniversity of California Irvine, Department of Epidemiology, Genetic Epidemiology Research Institute, Irvine, CA 92617, USA.
Kristan J AronsonQueen's University, Department of Public Health Sciences, and Cancer Research Institute, Kingston, ON K7L 3N6, Canada.
Annelie AugustinssonLund University, Department of Cancer Epidemiology, Clinical Sciences, Lund 222 42, Sweden.
Heiko BecherUniversity Medical Center Hamburg-Eppendorf, Institute of Medical Biometry and Epidemiology, Hamburg 20246, Germany; Charité -Universitätsmedizin Berlin, Institute of Biometry and Clinical Epidemiology, Berlin 10117, Germany.
Matthias W BeckmannUniversity Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, Erlangen 91054, Germany.
Sabine BehrensGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg 69120, Germany.
Javier BenitezCentro de Investigación en Red de Enfermedades Raras (CIBERER), Madrid 28029, Spain; Spanish National Cancer Research Centre (CNIO), Human Cancer Genetics Programme, Madrid 28029, Spain.
Marina BermishevaUfa Federal Research Centre of the Russian Academy of Sciences, Institute of Biochemistry and Genetics, Ufa 450054, Russia.
Natalia V BogdanovaHannover Medical School, Department of Radiation Oncology, Hannover 30625, Germany; Hannover Medical School, Gynaecology Research Unit, Hannover 30625, Germany; N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk 223040, Belarus.
Stig E BojesenCopenhagen University Hospital, Copenhagen General Population Study, Herlev and Gentofte Hospital, Herlev 2730, Denmark; Copenhagen University Hospital, Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Herlev 2730, Denmark; University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen 2200, Denmark.
Manjeet K BollaUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge CB1 8RN, UK.
Bernardo BonanniIEO, European Institute of Oncology IRCCS, Division of Cancer Prevention and Genetics, Milan 20141, Italy.
Hiltrud BrauchDr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart 70376, Germany; University of Tübingen, iFIT-Cluster of Excellence, Tübingen 72074, Germany; German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Partner Site Tübingen, Tübingen 72074, Germany.
Michael BremerHannover Medical School, Department of Radiation Oncology, Hannover 30625, Germany.
Sara Y BruckerUniversity of Tübingen, Department of Gynecology and Obstetrics, Tübingen 72076, Germany.
Barbara BurwinkelGerman Cancer Research Center (DKFZ), Molecular Epidemiology Group, C080, Heidelberg 69120, Germany; University of Heidelberg, Molecular Biology of Breast Cancer, University Womens Clinic Heidelberg, Heidelberg 69120, Germany.
Jose E CastelaoInstituto de Investigacion Sanitaria Galicia Sur (IISGS), Xerencia de Xestion Integrada de Vigo-SERGAS, Oncology and Genetics Unit, Vigo 36312, Spain.
Tsun L ChanHong Kong Hereditary Breast Cancer Family Registry, Hong Kong; Hong Kong Sanatorium and Hospital, Department of Pathology, Happy Valley, Hong Kong.
Jenny Chang-ClaudeGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg 69120, Germany; University Medical Center Hamburg-Eppendorf, Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), Hamburg 20246, Germany.
Stephen J ChanockNational Cancer Institute, National Institutes of Health, Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Bethesda, MD 20850, USA.
Georgia Chenevix-TrenchQIMR Berghofer Medical Research Institute, Department of Genetics and Computational Biology, Brisbane, QLD 4006, Australia.
Ji-Yeob ChoiSeoul National University Graduate School, Department of Biomedical Sciences, Seoul 03080, Korea; Seoul National University, Cancer Research Institute, Seoul 03080, Korea.
Christine L ClarkeUniversity of Sydney, Westmead Institute for Medical Research, Sydney, NSW 2145, Australia.
NBCS CollaboratorsOslo University Hospital-Radiumhospitalet, Department of Cancer Genetics, Institute for Cancer Research, Oslo 0379, Norway; University of Oslo, Institute of Clinical Medicine, Faculty of Medicine, Oslo 0450, Norway; Vestre Viken Hospital, Department of Research, Drammen 3019, Norway; Oslo University Hospital-Ullevål, Section for Breast and Endocrine Surgery, Department of Cancer, Division of Surgery, Cancer and Transplantation Medicine, Oslo 0450, Norway; Oslo University Hospital, Department of Radiology and Nuclear Medicine, Oslo 0379, Norway; Akershus University Hospital, Department of Pathology, Lørenskog 1478, Norway; Oslo University Hospital, Department of Tumor Biology, Institute for Cancer Research, Oslo 0379, Norway; Oslo University Hospital-Radiumhospitalet, Department of Oncology, Division of Surgery, Cancer and Transplantation Medicine, Oslo 0379, Norway; Oslo University Hospital-Radiumhospitalet, National Advisory Unit on Late Effects after Cancer Treatment, Department of Oncology, Oslo 0379, Norway; Akershus University Hospital, Department of Oncology, Lørenskog 1478, Norway; Oslo University Hospital, Oslo Breast Cancer Research Consortium, Oslo 0379, Norway; Oslo University Hospital and University of Olso, Department of Medical Genetics, Oslo 0379, Norway.
J Margriet ColléeErasmus University Medical Center, Department of Clinical Genetics, Rotterdam 3015 CN, the Netherlands.
Fergus J CouchMayo Clinic, Department of Laboratory Medicine and Pathology, Rochester, MN 55905, USA.
Angela CoxUniversity of Sheffield, Sheffield Institute for Nucleic Acids (SInFoNiA), Department of Oncology and Metabolism, Sheffield S10 2TN, UK.
Simon S CrossUniversity of Sheffield, Academic Unit of Pathology, Department of Neuroscience, Sheffield S10 2TN, UK.
Kamila CzeneKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm 171 65, Sweden.
Mary B DalyFox Chase Cancer Center, Department of Clinical Genetics, Philadelphia, PA 19111, USA.
Peter DevileeLeiden University Medical Center, Department of Pathology, Leiden 2333 ZA, the Netherlands; Leiden University Medical Center, Department of Human Genetics, Leiden 2333 ZA, the Netherlands.
Thilo DörkHannover Medical School, Gynaecology Research Unit, Hannover 30625, Germany.
Isabel Dos-Santos-SilvaLondon School of Hygiene and Tropical Medicine, Department of Non-Communicable Disease Epidemiology, London WC1E 7HT, UK.
Alison M DunningUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge CB1 8RN, UK.
Miriam DwekUniversity of Westminster, School of Life Sciences, London W1B 2HW, UK.
Diana M EcclesUniversity of Southampton, Faculty of Medicine, Southampton SO17 1BJ, UK.
D Gareth EvansUniversity of Manchester, Manchester Academic Health Science Centre, Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester M13 9WL, UK; St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, Manchester M13 9WL, UK.
Peter A FaschingUniversity Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, Erlangen 91054, Germany; University of California at Los Angeles, David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, Los Angeles, CA 90095, USA.
Henrik FlygerCopenhagen University Hospital, Department of Breast Surgery, Herlev and Gentofte Hospital, Herlev 2730, Denmark.
Manuela Gago-DominguezGrupo de Medicina Xenómica, Instituto de Investigación Sanitaria de Santiago de Compostela (IDIS), Fundación Pública Galega de Medicina Xenómica, Santiago de Compostela 15706, Spain; University of California San Diego, Moores Cancer Center, La Jolla, CA 92037, USA.
Montserrat García-ClosasNational Cancer Institute, National Institutes of Health, Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, Bethesda, MD 20850, USA.
José A García-SáenzInstituto de Investigación Sanitaria San Carlos (IdISSC), Centro Investigación Biomédica en Red de Cáncer (CIBERONC), Medical Oncology Department, Hospital Clínico San Carlos, Madrid 28040, Spain.
Graham G GilesCancer Council Victoria, Cancer Epidemiology Division, Melbourne, VIC 3004, Australia; The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, VIC 3010, Australia; Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, VIC 3168, Australia.
David E GoldgarHuntsman Cancer Institute, University of Utah School of Medicine, Department of Dermatology, Salt Lake City, UT 84112, USA.
Anna González-NeiraSpanish National Cancer Research Centre (CNIO), Human Cancer Genetics Programme, Madrid 28029, Spain.
Christopher A HaimanUniversity of Southern California, Department of Preventive Medicine, Keck School of Medicine, Los Angeles, CA 90033, USA.
Niclas HåkanssonKarolinska Institutet, Institute of Environmental Medicine, Stockholm 171 77, Sweden.
Ute HamannGerman Cancer Research Center (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg 69120, Germany.
Mikael HartmanNational University of Singapore and National University Health System, Saw Swee Hock School of Public Health, Singapore 119077, Singapore; National University Health System, Department of Surgery, Singapore 119228, Singapore.
Bernadette A M Heemskerk-GerritsenErasmus MC Cancer Institute, Department of Medical Oncology, Rotterdam 3015 CN, the Netherlands.
Antoinette HollestelleErasmus MC Cancer Institute, Department of Medical Oncology, Rotterdam 3015 CN, the Netherlands.
John L HopperThe University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, VIC 3010, Australia.
Ming-Feng HouKaohsiung Medical University, Chung-Ho Memorial Hospital, Kaohsiung 807, Taiwan.
Anthony HowellUniversity of Manchester, Division of Cancer Sciences, Manchester M13 9PL, UK.
ABCTB InvestigatorsUniversity of Sydney, Australian Breast Cancer Tissue Bank, Westmead Institute for Medical Research, Sydney, NSW 2145, Australia.
kConFab InvestigatorsPeter MacCallum Cancer Center, Melbourne, VIC 3000, Australia; The University of Melbourne, Sir Peter MacCallum Department of Oncology, Melbourne, VIC 3000, Australia.
Hidemi ItoAichi Cancer Center Research Institute, Division of Cancer Epidemiology and Prevention, Nagoya 464-8681, Japan; Nagoya University Graduate School of Medicine, Division of Cancer Epidemiology, Nagoya 466-8550, Japan.
Milena JakimovskaMASA, Research Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', Skopje 1000, Republic of North Macedonia.
Anna JakubowskaPomeranian Medical University, Department of Genetics and Pathology, Szczecin 71-252, Poland; Pomeranian Medical University, Independent Laboratory of Molecular Biology and Genetic Diagnostics, Szczecin 71-252, Poland.
Wolfgang JanniUniversity Hospital Ulm, Department of Gynaecology and Obstetrics, Ulm 89075, Germany.
Esther M JohnStanford Cancer Institute, Stanford University School of Medicine, Department of Epidemiology & Population Health, Stanford, CA 94304, USA.
Audrey JungGerman Cancer Research Center (DKFZ), Division of Cancer Epidemiology, Heidelberg 69120, Germany.
Daehee KangSeoul National University Graduate School, Department of Biomedical Sciences, Seoul 03080, Korea; Seoul National University, Cancer Research Institute, Seoul 03080, Korea; Seoul National University College of Medicine, Department of Preventive Medicine, Seoul 03080, Korea.
C Marleen Ketsthe Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Department of Clinical Genetics, Amsterdam 1066 CX, the Netherlands.
Elza KhusnutdinovaUfa Federal Research Centre of the Russian Academy of Sciences, Institute of Biochemistry and Genetics, Ufa 450054, Russia; Bashkir State University, Department of Genetics and Fundamental Medicine, Ufa 450000, Russia.
Yon-Dschun KoJohanniter Krankenhaus, Department of Internal Medicine, Evangelische Kliniken Bonn gGmbH, Bonn 53177, Germany.
Vessela N KristensenOslo University Hospital-Radiumhospitalet, Department of Cancer Genetics, Institute for Cancer Research, Oslo 0379, Norway; Oslo University Hospital and University of Olso, Department of Medical Genetics, Oslo 0379, Norway.
Allison W KurianStanford Cancer Institute, Stanford University School of Medicine, Department of Epidemiology & Population Health, Stanford, CA 94304, USA; Stanford University School of Medicine, Department of Health Research and Policy, Stanford, CA 94305, USA.
Ava KwongHong Kong Hereditary Breast Cancer Family Registry, Hong Kong; The University of Hong Kong, Department of Surgery, Pok Fu Lam, Hong Kong; Hong Kong Sanatorium and Hospital, Cancer Genetics Center and Department of Surgery, Happy Valley, Hong Kong.
Diether LambrechtsVIB Center for Cancer Biology, Leuven 3001, Belgium; University of Leuven, Laboratory for Translational Genetics, Department of Human Genetics, Leuven 3000, Belgium.
Loic Le MarchandUniversity of Hawaii Cancer Center, Epidemiology Program, Honolulu, HI 96813, USA.
Jingmei LiGenome Institute of Singapore, Human Genetics Division, Singapore 138672, Singapore.
Annika LindblomKarolinska Institutet, Department of Molecular Medicine and Surgery, Stockholm 171 76, Sweden; Karolinska University Hospital, Department of Clinical Genetics, Stockholm 171 76, Sweden.
Jan LubińskiPomeranian Medical University, Department of Genetics and Pathology, Szczecin 71-252, Poland.
Arto MannermaaUniversity of Eastern Finland, Translational Cancer Research Area, Kuopio 70210, Finland; University of Eastern Finland, Institute of Clinical Medicine, Pathology and Forensic Medicine, Kuopio 70210, Finland; Kuopio University Hospital, Biobank of Eastern Finland, Kuopio 70210, Finland.
Mehdi ManoochehriGerman Cancer Research Center (DKFZ), Molecular Genetics of Breast Cancer, Heidelberg 69120, Germany.
Sara MargolinSödersjukhuset, Department of Oncology, Stockholm 118 83, Sweden; Karolinska Institutet, Department of Clinical Science and Education, Södersjukhuset, Stockholm 118 83, Sweden.
Keitaro MatsuoAichi Cancer Center Research Institute, Division of Cancer Epidemiology and Prevention, Nagoya 464-8681, Japan; Nagoya University Graduate School of Medicine, Division of Cancer Epidemiology, Nagoya 466-8550, Japan.
Dimitrios MavroudisUniversity Hospital of Heraklion, Department of Medical Oncology, Heraklion 711 10, Greece.
Alfons MeindlUniversity of Munich, Campus Großhadern, Department of Gynecology and Obstetrics, Munich 81377, Germany.
Roger L MilneCancer Council Victoria, Cancer Epidemiology Division, Melbourne, VIC 3004, Australia; The University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, VIC 3010, Australia; Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, VIC 3168, Australia.
Anna Marie MulliganUniversity of Toronto, Department of Laboratory Medicine and Pathobiology, Toronto, ON M5S 1A8, Canada; University Health Network, Laboratory Medicine Program, Toronto, ON M5G 2C4, Canada.
Taru A MuranenHelsinki University Hospital, Department of Obstetrics and Gynecology, University of Helsinki, Helsinki 00290, Finland.
Susan L NeuhausenBeckman Research Institute of City of Hope, Department of Population Sciences, Duarte, CA 91010, USA.
Heli NevanlinnaHelsinki University Hospital, Department of Obstetrics and Gynecology, University of Helsinki, Helsinki 00290, Finland.
William G NewmanUniversity of Manchester, Manchester Academic Health Science Centre, Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester M13 9WL, UK; St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, Manchester M13 9WL, UK.
Andrew F OlshanUniversity of North Carolina at Chapel Hill, Department of Epidemiology, Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.
Janet E OlsonMayo Clinic, Department of Health Sciences Research, Rochester, MN 55905, USA.
Håkan OlssonLund University, Department of Cancer Epidemiology, Clinical Sciences, Lund 222 42, Sweden.
Tjoung-Won Park-SimonHannover Medical School, Gynaecology Research Unit, Hannover 30625, Germany.
Julian PetoLondon School of Hygiene and Tropical Medicine, Department of Non-Communicable Disease Epidemiology, London WC1E 7HT, UK.
Christos PetridisKing's College London, Research Oncology, Guy's Hospital, London SE1 9RT, UK.
Dijana Plaseska-KaranfilskaMASA, Research Centre for Genetic Engineering and Biotechnology 'Georgi D. Efremov', Skopje 1000, Republic of North Macedonia.
Nadege PresneauUniversity of Westminster, School of Life Sciences, London W1B 2HW, UK.
Katri PylkäsUniversity of Oulu, Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, Oulu 90220, Finland; Northern Finland Laboratory Centre Oulu, Laboratory of Cancer Genetics and Tumor Biology, Oulu 90220, Finland.
Paolo RadiceFondazione IRCCS Istituto Nazionale dei Tumori (INT), Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Milan 20133, Italy.
Gad RennertCarmel Medical Center and Technion Faculty of Medicine, Clalit National Cancer Control Center, Haifa 35254, Israel.
Atocha RomeroHospital Universitario Puerta de Hierro, Medical Oncology Department, Madrid 28222, Spain.
Rebecca RoylanceUCLH Foundation Trust, Department of Oncology, London NW1 2PG, UK.
Emmanouil SaloustrosUniversity Hospital of Larissa, Department of Oncology, Larissa 411 10, Greece.
Elinor J SawyerKing's College London, School of Cancer & Pharmaceutical Sciences, Comprehensive Cancer Centre, Guy's Campus, London SE1 1UL, UK.
Rita K SchmutzlerFaculty of Medicine and University Hospital Cologne, University of Cologne, Center for Familial Breast and Ovarian Cancer, Cologne 50937, Germany; Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Integrated Oncology (CIO), Cologne 50937, Germany; Faculty of Medicine and University Hospital Cologne, University of Cologne, Center for Molecular Medicine Cologne (CMMC), Cologne 50931, Germany.
Lukas SchwentnerUniversity Hospital Ulm, Department of Gynaecology and Obstetrics, Ulm 89075, Germany.
Christopher ScottMayo Clinic, Department of Health Sciences Research, Rochester, MN 55905, USA.
Mee-Hoong SeeUniversity of Malaya, Breast Cancer Research Unit, University Malaya Cancer Research Institute, Faculty of Medicine, Kuala Lumpur 50603, Malaysia.
Mitul ShahUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge CB1 8RN, UK.
Chen-Yang ShenAcademia Sinica, Institute of Biomedical Sciences, Taipei 115, Taiwan; China Medical University, School of Public Health, Taichung 40402, Taiwan.
Xiao-Ou ShuVanderbilt University School of Medicine, Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA.
Sabine SieslingNetherlands Comprehensive Cancer Organisation (IKNL), Department of Research, Utrecht 3511 DT, the Netherlands; University of Twente, Department of Health Technology and Service Research, Technical Medical Center, Enschede 7522 NB, the Netherlands.
Susan SlagerMayo Clinic, Department of Health Sciences Research, Rochester, MN 55905, USA.
Christof SohnUniversity Hospital and German Cancer Research Center, National Center for Tumor Diseases, Heidelberg 69120, Germany.
Melissa C SoutheyCancer Council Victoria, Cancer Epidemiology Division, Melbourne, VIC 3004, Australia; Monash University, Precision Medicine, School of Clinical Sciences at Monash Health, Clayton, VIC 3168, Australia; The University of Melbourne, Department of Clinical Pathology, Melbourne, VIC 3010, Australia.
John J SpinelliBC Cancer, Population Oncology, Vancouver, BC V5Z 1G1, Canada; University of British Columbia, School of Population and Public Health, Vancouver, BC V6T 1Z4, Canada.
Jennifer StoneThe University of Melbourne, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Melbourne, VIC 3010, Australia; Curtin University and University of Western Australia, The Curtin UWA Centre for Genetic Origins of Health and Disease, Perth, WA 6000, Australia.
William J TapperUniversity of Southampton, Faculty of Medicine, Southampton SO17 1BJ, UK.
Maria TengströmUniversity of Eastern Finland, Translational Cancer Research Area, Kuopio 70210, Finland; Kuopio University Hospital, Department of Oncology, Cancer Center, Kuopio 70210, Finland; University of Eastern Finland, Institute of Clinical Medicine, Oncology, Kuopio 70210, Finland.
Soo Hwang TeoCancer Research Malaysia, Breast Cancer Research Programme, Subang Jaya, Selangor 47500, Malaysia; University of Malaya, Department of Surgery, Faculty of Medicine, Kuala Lumpur 50603, Malaysia.
Mary Beth TerryColumbia University, Department of Epidemiology, Mailman School of Public Health, New York, NY 10032, USA.
Rob A E M TollenaarLeiden University Medical Center, Department of Surgery, Leiden 2333 ZA, the Netherlands.
Ian TomlinsonUniversity of Birmingham, Institute of Cancer and Genomic Sciences, Birmingham B15 2TT, UK; University of Oxford, Wellcome Trust Centre for Human Genetics and Oxford NIHR Biomedical Research Centre, Oxford OX3 7BN, UK.
Melissa A TroesterUniversity of North Carolina at Chapel Hill, Department of Epidemiology, Gillings School of Global Public Health and UNC Lineberger Comprehensive Cancer Center, Chapel Hill, NC 27599, USA.
Celine M VachonMayo Clinic, Department of Health Science Research, Division of Epidemiology, Rochester, MN 55905, USA.
Chantal van OngevalLeuven Cancer Institute, University Hospitals Leuven, Leuven Multidisciplinary Breast Center, Department of Radiology, Leuven 3000, Belgium.
Elke M van VeenUniversity of Manchester, Manchester Academic Health Science Centre, Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester M13 9WL, UK; St Mary's Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, North West Genomics Laboratory Hub, Manchester Centre for Genomic Medicine, Manchester M13 9WL, UK.
Robert WinqvistUniversity of Oulu, Laboratory of Cancer Genetics and Tumor Biology, Cancer and Translational Medicine Research Unit, Biocenter Oulu, Oulu 90220, Finland; Northern Finland Laboratory Centre Oulu, Laboratory of Cancer Genetics and Tumor Biology, Oulu 90220, Finland.
Alicja WolkKarolinska Institutet, Institute of Environmental Medicine, Stockholm 171 77, Sweden; Uppsala University, Department of Surgical Sciences, Uppsala 751 05, Sweden.
Wei ZhengVanderbilt University School of Medicine, Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Nashville, TN 37232, USA.
Argyrios ZiogasUniversity of California Irvine, Department of Epidemiology, Genetic Epidemiology Research Institute, Irvine, CA 92617, USA.
Douglas F EastonUniversity of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Cambridge CB1 8RN, UK; University of Cambridge, Centre for Cancer Genetic Epidemiology, Department of Oncology, Cambridge CB1 8RN, UK.
Per HallKarolinska Institutet, Department of Medical Epidemiology and Biostatistics, Stockholm 171 65, Sweden; Södersjukhuset, Department of Oncology, Stockholm 118 83, Sweden.
Marjanka K SchmidtThe Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital, Division of Molecular Pathology, Amsterdam 1066 CX, the Netherlands; The Netherlands Cancer Institute - Antoni van Leeuwenhoek hospital, Division of Psychosocial Research and Epidemiology, Amsterdam 1066 CX, the Netherlands. Electronic address: mk.schmidt@nki.nl.
University of Cambridge · GBGerman Cancer Research Center · DEMayo Clinic in Florida · USThe University of Melbourne · AUMedizinische Hochschule Hannover · DEThe Netherlands Cancer Institute · NLManchester Academic Health Science Centre · GBLeiden University Medical Center · NLAichi Cancer Center · JPCancer Council Victoria · AUKarolinska Institutet · SELondon School of Hygiene & Tropical Medicine · GBUniversity of Eastern Finland · FIUniversity of Helsinki · FIUniversity of North Carolina at Chapel Hill · USVanderbilt University · USCarmel Medical Center · ILHong Kong Sanatorium and Hospital · HKLund University · SEMacedonian Academy of Sciences and Arts · MK

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Cancer Research UK 11174Cancer Research UK 16563Cancer Research UK 16565Cancer Research UK 20861NIEHS NIH HHS P30 ES010126Wellcome Trust 203477/Z/16/Z
6 · The paper itself

Abstract

Previous research has shown that polygenic risk scores (PRSs) can be used to stratify women according to their risk of developing primary invasive breast cancer. This study aimed to evaluate the association between a recently validated PRS of 313 germline variants (PRS

Indexed as

Genetic Predisposition to DiseaseGenome, HumanMultifactorial InheritanceAdultAgedAsian PeopleBreast NeoplasmsCohort StudiesErb-b2 Receptor Tyrosine KinasesEstrogen Receptor alphaFemaleGene ExpressionGenome-Wide Association StudyHumansMiddle AgedNeoadjuvant TherapyERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesESR1 protein, humanEstrogen Receptor alphaReceptors, Progesteronecontralateral breast cancerepidemiologygeneticpolygenic risk score

Identifiers

PMID33022221
PMCPMC7675034
OpenAlexW3091099371

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