Evidence map›Paper›PMID 33022112›Full record

ArticleThe Laryngoscope2021

Hybrid Three-Dimensional-Printed Ear Tissue Scaffold With Autologous Cartilage Mitigates Soft Tissue Complications.

Brian Chang, Ashley Cornett, Zahra Nourmohammadi, Jadan Law, Blaine Weld, Sarah J Crotts, Scott J Hollister, Isabelle M A Lombaert, David A Zopf

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  5. [Research progress of three-dimensional bioprinting technology in auricle repair and reconstruction].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Brian ChangDepartment of Pediatrics, University of California Los Angeles Mattel Children's Hospital, Los Angeles, California, U.S.A.ORCID 0000-0001-5165-7051
Ashley CornettDepartment of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, U.S.A.
Zahra NourmohammadiDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan, U.S.A.
Jadan LawDepartment of Biomedical Engineering, Michigan Engineering, Ann and Robert H. Lurie Biomedical Engineering Building, Ann Arbor, Michigan, U.S.A.
Blaine WeldDepartment of Biomedical Engineering, Michigan Engineering, Ann and Robert H. Lurie Biomedical Engineering Building, Ann Arbor, Michigan, U.S.A.
Sarah J CrottsCenter for 3D Medical Fabrication, Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, U.S.A.
Scott J HollisterCenter for 3D Medical Fabrication, Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, U.S.A.
Isabelle M A LombaertDepartment of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan, U.S.A.
David A ZopfDepartment of Biomedical Engineering, Michigan Engineering, Ann and Robert H. Lurie Biomedical Engineering Building, Ann Arbor, Michigan, U.S.A.
University of Michigan · USGeorgia Institute of Technology · USMattel Children's Hospital · US

Funding

NRSA Training CoreTL1TR002242 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI HOLINSTAT, MICHAEL ALLAN · 2017 to 2021
$2.8M
MicroCT 100S10RR026475 · NCRR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KOHN, DAVID H. · 2010 to 2010
$381k
NCATS NIH HHS TL1 TR002242NCRR NIH HHS S10 RR026475
6 · The paper itself

Abstract

objectives/hypothesisTo analyze the use of highly translatable three-dimensional (3D)-printed auricular scaffolds with and without novel cartilage tissue inserts in a rodent model. STUDY

designPreclinical rodent animal model.

methodsThis prospective study assessed a single-stage 3D-printed auricular bioscaffold with or without porcine cartilage tissue inserts in an athymic rodent model. Digital Imaging and Communications in Medicine computed tomography images of a human auricle were segmented to create an external anatomic envelope filled with orthogonally interconnected spherical pores. Scaffolds with and without tissue inset sites were 3D printed by laser sintering bioresorbable polycaprolactone, then implanted subcutaneously in five rats for each group.

resultsTen athymic rats were studied to a goal of 24 weeks postoperatively. Precise anatomic similarity and scaffold integrity were maintained in both scaffold conditions throughout experimentation with grossly visible tissue ingrowth and angiogenesis upon explantation. Cartilage-seeded scaffolds had relatively lower rates of nonsurgical site complications compared to unseeded scaffolds with relatively increased surgical site ulceration, though neither met statistical significance. Histology revealed robust soft tissue infiltration and vascularization in both seeded and unseeded scaffolds, and demonstrated impressive maintenance of viable cartilage in cartilage-seeded scaffolds. Radiology confirmed soft tissue infiltration in all scaffolds, and biomechanical modeling suggested amelioration of stress in scaffolds implanted with cartilage.

conclusionsA hybrid approach incorporating cartilage insets into 3D-printed bioscaffolds suggests enhanced clinical and histological outcomes. These data demonstrate the potential to integrate point-of-care tissue engineering techniques into 3D printing to generate alternatives to current reconstructive surgery techniques and avoid the demands of traditional tissue engineering. LEVEL OF EVIDENCE: NA Laryngoscope, 131:1008-1015, 2021.

Indexed as

Printing, Three-DimensionalTissue ScaffoldsAnimalsBiopsyChildChondrogenesisComputer-Aided DesignCostal CartilageDisease Models, AnimalEar AuricleEar CartilageHumansMalePhotographyPlastic Surgery ProceduresPolyesterspolycaprolactonePolyestersauricular reconstructionThree-dimensional printingtissue engineering

Identifiers

PMID33022112
PMCPMC8021596
OpenAlexW3092382083

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.