Evidence map›Paper›PMID 33022047›Full record

ArticleMolecular human reproduction2020

Unscrambling the oocyte and the egg: clarifying terminology of the female gamete in mammals.

Francesca E Duncan, Karen Schindler, Richard M Schultz, Cecilia S Blengini, Paula Stein, Stephen A Stricker, Gary M Wessel, Carmen J Williams

Open access · greenAbstract readEditorial
In one paragraph

Article in Molecular human reproduction, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Approaches toAnimal reproduction · 2025
    Article
  4. Review
  5. Article
  6. Article
  7. Review
  8. Same gene, opposite sexes: Sex-specific divergent expression of a gene required for vertebrate fertilization.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Francesca E DuncanDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Chicago, IL, USA.
Karen SchindlerDepartment of Genetics, Rutgers University, New Brunswick, NJ, USA.
Richard M SchultzDepartment of Biology, University of Pennsylvania, Philadelphia, PA, USA.
Cecilia S BlenginiDepartment of Genetics, Rutgers University, New Brunswick, NJ, USA.
Paula SteinReproductive Medicine Group, National Institute of Environmental Health Sciences, Durham, NC, USA.
Stephen A StrickerDepartment of Biology, University of New Mexico, Albuquerque, NM, USA.
Gary M WesselDepartment of Molecular, Cellular Biology and Biochemistry, Brown University, Providence, RI, USA.
Carmen J WilliamsReproductive Medicine Group, National Institute of Environmental Health Sciences, Durham, NC, USA.
National Institute of Environmental Health Sciences · USRutgers, The State University of New Jersey · USBrown University · USUniversity of New Mexico · USUniversity of Pennsylvania · US

Funding

Control of mammalian meiosis I through protein kinase signalingR01GM112801 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI SCHINDLER, KAREN A · 2015 to 2019
$1.9M
Homeostatic to reactive hyaluronan matrices in ovarian reproductive agingR01HD093726 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DUNCAN, FRANCESCA E., PRITCHARD, MICHELE T · 2018 to 2022
$1.6M
Mechanisms of quiescence in primordial germ cellsR01GM125071 · NIGMS · BROWN UNIVERSITY · PI WESSEL, GARY M · 2017 to 2020
$1.4M
Sequential restriction of germ line progenitors by inductionR01GM132222 · NIGMS · BROWN UNIVERSITY · PI WESSEL, GARY M · 2019 to 2020
$694k
Extremely Long Lived Proteins and Female Reproductive AgingR21HD098498 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI DUNCAN, FRANCESCA E., SAVAS, JEFFREY NICHOLAS · 2019 to 2020
$460k
NICHD NIH HHS R01 HD093726NICHD NIH HHS R21 HD098498NIGMS NIH HHS R01 GM112801NIGMS NIH HHS R01 GM125071NIGMS NIH HHS R01 GM132222
6 · The paper itself

Abstract

Most reproductive biologists who study female gametes will agree with the 16th century anatomist William Harvey's doctrine: 'Ex Ovo Omnia'. This phrase, which literally translates to 'everything from the egg', recognizes the centrality of the egg in animal development. Eggs are most impressive cells, capable of supporting development of an entirely new organism following fertilization or parthenogenetic activation. Not so uniformly embraced in the field of reproductive biology is the nomenclature used to refer to the female germ cell. What is an oocyte? What is an egg? Are these terms the same, different, interchangeable? Here we provide functional definitions of the oocyte and egg, and how they can be used in the context of mammalian gamete biology and beyond.

Indexed as

AnimalsFemaleGerm CellsHumansMammalsOocytesOogenesisOvumTerminology as Topicegggamete / mammalianoocyteoocyte maturation

Identifiers

PMID33022047
PMCPMC7648930
OpenAlexW3092643377

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.