ArticleNeuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition2021
Dopamine effects on memory load and distraction during visuospatial working memory in cognitively normal Parkinson's disease.
Article in Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 8 citations in OpenAlex.
- Microsaccade Activity During Visuospatial Working Memory in Early-Stage Parkinson's Disease.Journal of eye movement research · 2025Article
- Dopaminergic medication normalizes aberrant cognitive control circuit signalling in Parkinson's disease.Brain : a journal of neurology · 2022Article
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6 authors at 2 institutions in 1 country.
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Abstract
Visuospatial working memory (WM) impairments in Parkinson's disease (PD) are more prominent and evolve earlier than verbal WM deficits, suggesting some differences in underlying pathology. WM is regulated by dopaminergic neurotransmission in the prefrontal cortex, but the effect of dopamine on specific processes supporting visuospatial WM are not well understood. Dopamine therapeutic effects on different WM processes may also differ given the heterogeneity of cognitive changes in PD. The present study examined the effect of dopamine therapy on memory load and distraction during visuospatial WM. Exploratory analyses evaluated whether individual differences in medication effects were associated with a gene, catechol-O-methyltransferase (COMT), which regulates prefrontal cortex dopamine levels. Cognitively normal PD participants (n = 28) and controls (n = 25) performed a visuospatial WM task, which manipulated memory load and the presence/absence of distractors. PD participants performed the task
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