Evidence map›Paper›PMID 33021418›Full record

SynthesisOcular immunology and inflammation2022

Noninvasive Instrument-based Tests for Detecting and Measuring Vitreous Inflammation in Uveitis: A Systematic Review.

Xiaoxuan Liu, Benjamin Tk Hui, Christopher Way, Sophie Beese, Ada Adriano, Pearse A Keane, David J Moore, Alastair K Denniston

Open access · hybridAbstract readSystematic Review
In one paragraph

Synthesis in Ocular immunology and inflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. OCT Assisted Quantification of Vitreous Inflammation in Uveitis.Translational vision science & technology · 2022
    Article
  4. Article
  5. Monitoring Behçet uveitis.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological Society
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Xiaoxuan LiuOphthalmology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.ORCID 0000-0002-1286-0038
Benjamin Tk HuiOphthalmology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
Christopher WayMusgrove Park Hospital, Taunton and Somerset NHS Foundation Trust, Taunton, UK.
Sophie BeeseInstitute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham UK.
Ada AdrianoInstitute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham UK.
Pearse A KeaneNIHR Biomedical Research Centre for Ophthalmology, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, UK.
David J MooreInstitute of Applied Health Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham UK.
Alastair K DennistonOphthalmology Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.ORCID 0000-0001-7849-0087
University Hospitals Birmingham NHS Foundation Trust · GBUniversity of Birmingham · GBMoorfields Eye Hospital NHS Foundation Trust · GBMusgrove Park Hospital · GB

Funding

Department of Health CS-2014-14-023Medical Research Council MR/T019050/1Wellcome Trust 200141/Z/15/Z
6 · The paper itself

Abstract

purposeThis systematic review aims to identify instrument-based tests for quantifying vitreous inflammation in uveitis, report the test reliability and the level of correlation with clinician grading.

methodsStudies describing instrument-based tests for detecting vitreous inflammation were identified by searching bibliographic databases and trials registers. Test reliability measures and level of correlation with clinician vitreous haze grading are extracted.

resultsTwelve studies describing ultrasound, optical coherence tomography (OCT), and retinal photography for detecting vitreous inflammation were included: Ultrasound was used for detection of disease features, whereas OCT and retinal photography provided quantifiable measurements. Correlation with clinician grading for OCT was 0.53-0.60 (three studies) and for retinal photography was 0.51 (1 study). Both instruments showed high inter- and intra-observer reliability (>0.70 intraclass correlation and Cohen's kappa), where reported in four studies.

conclusionRetinal photography and OCT are able to detect and measure vitreous inflammation. Both techniques are reliable, automatable, and warrant further evaluation.

Indexed as

UveitisHumansInflammationReproducibility of ResultsTomography, Optical Coherencediagnostic testimagingoptical coherence tomographyretinal photographySystematic reviewultrasounduveitisvitreousvitreous inflammationvitritis

Identifiers

PMID33021418
PMCPMC8935946
OpenAlexW3089611818

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.