Evidence map›Paper›PMID 33021416›Full record

ReviewInternational journal of radiation biology2023

Advancements in the use of Auger electrons in science and medicine during the period 2015-2019.

Roger W Howell

Abstract readReview
In one paragraph

Review in International journal of radiation biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Efficacy and safety of [Frontiers in medicine · 2026
    Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Review
  9. Marshalling the Potential of Auger Electron Radiopharmaceutical Therapy.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2023
    Review
  10. MIRD Pamphlet No. 27: MIRDcell V3, a Revised Software Tool for Multicellular Dosimetry and Bioeffect Modeling.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Article
  11. Radionuclides for Targeted Therapy: Physical Properties.Molecules (Basel, Switzerland) · 2022
    Review
  12. Article
  13. Article
  14. Auger: The future of precision medicine.Nuclear medicine and biology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Roger W HowellDivision of Radiation Research, Department of Radiology, New Jersey Medical School, Rutgers University, Newark, NJ, USA.ORCID 0000-0002-7057-8110

Funding

MIRDcell Version 3R01CA245139 · NCI · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Roger W. Howell · 2020 to 2026
$1.8M
Radiation induced bystander effects in radium-223 therapyR01CA198073 · NCI · RBHS-NEW JERSEY MEDICAL SCHOOL · PI AZZAM, EDOUARD I, HOWELL, ROGER W. · 2015 to 2018
$1.3M
NCI NIH HHS R01 CA198073NCI NIH HHS R01 CA245139
6 · The paper itself

Abstract

Auger electrons can be highly radiotoxic when they are used to irradiate specific molecular sites. This has spurred basic science investigations of their radiobiological effects and clinical investigations of their potential for therapy. Focused symposia on the biophysical aspects of Auger processes have been held quadrennially. This 9th International Symposium on Physical, Molecular, Cellular, and Medical Aspects of Auger Processes at Oxford University brought together scientists from many different fields to review past findings, discuss the latest studies, and plot the future work to be done. This review article examines the research in this field that was published during the years 2015-2019 which corresponds to the period since the last meeting in Japan. In addition, this article points to future work yet to be done. There have been a plethora of advancements in our understanding of Auger processes. These advancements range from basic atomic and molecular physics to new ways to implement Auger electron emitters in radiopharmaceutical therapy. The highly localized doses of radiation that are deposited within a 10 nm of the decay site make them precision tools for discovery across the physical, chemical, biological, and medical sciences.

Indexed as

ElectronsMedicineHumansIodine RadioisotopesJapanRadiobiologyIodine RadioisotopesAuger electronsDNA damageradionuclideradiopharmaceutical therapy

Identifiers

PMID33021416
PMCPMC8062591

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.