Evidence map›Paper›PMID 33021413›Full record

ArticleThe Journal of international medical research2020

Heat-killed

Zebin Liao, Zhe Liu, Zhenyu Gong, Xuguang Hu, Yuanyuan Chen, Kun Cao, Hong Zhang, Lu Gan, Juxiang Chen, Yanyong Yang and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Zebin LiaoDepartment of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, P.R. China.
Zhe LiuDepartment of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, P.R. China.
Zhenyu GongDepartment of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, P.R. China.
Xuguang HuDepartment of Gastrointestinal Surgery, Changhai Hospital, Shanghai, P. R. China.
Yuanyuan ChenDepartment of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, P.R. China.
Kun CaoDepartment of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, P.R. China.
Hong ZhangInstitute of Modern Physics, Chinese Academy of Sciences, Lanzhou, P. R. China.
Lu GanInstitute of Modern Physics, Chinese Academy of Sciences, Lanzhou, P. R. China.
Juxiang ChenDepartment of Neurosurgery, Changzheng Hospital, Second Military Medical University, Shanghai, P.R. China.
Yanyong YangDepartment of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, P.R. China.ORCID https://orcid.org/0000-0002-6882-5274
Jianming CaiDepartment of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, P.R. China.
Second Military Medical University · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivePatients receiving carbon-ion radiation therapy and astronauts exploring outer space are inevitably exposed to heavy ion radiation. The aim of this study was to develop radioprotectors to minimize the injuries induced by carbon ion radiation.

methodsHeat-killed

resultsInjuries induced by carbon ion radiation were significantly eased by pretreatment with HKST. Both apoptosis and high expression levels of pro-apoptotic proteins induced by heavy ion radiation were inhibited by HKST pretreatment. The radioprotective effect of HKST was associated with stimulation of Toll-like receptor signaling mediated by enhanced IRF3 and IRF7 signaling.

conclusionHKST was an effective radioprotector alleviating damage to multiple organs caused by heavy ion radiation.

Indexed as

Hot TemperatureSalmonella typhimuriumAnimalsApoptosisCarbonHumansMaleMiceTestisCarbonapoptosisCarbon ion radiationheat-killed Salmonella TyphimuriumIRF3/7radioprotectorToll-like receptors

Identifiers

PMID33021413
PMCPMC7543184
OpenAlexW3090134730

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.