Evidence map›Paper›PMID 33021200›Full record

ArticleeLife2020

Ubiquitin-dependent regulation of a conserved DMRT protein controls sexually dimorphic synaptic connectivity and behavior.

Emily A Bayer, Rebecca C Stecky, Lauren Neal, Phinikoula S Katsamba, Goran Ahlsen, Vishnu Balaji, Thorsten Hoppe, Lawrence Shapiro, Meital Oren-Suissa, Oliver Hobert

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
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  4. A conservedbioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Emily A BayerDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.ORCID 0000-0002-5254-9199
Rebecca C SteckyDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.
Lauren NealDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.
Phinikoula S KatsambaDepartment of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, United States.
Goran AhlsenDepartment of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, United States.
Vishnu BalajiInstitute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Thorsten HoppeInstitute for Genetics and Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Lawrence ShapiroDepartment of Biochemistry and Molecular Biophysics, Columbia University Irving Medical Center, New York, United States.ORCID 0000-0001-9943-8819
Meital Oren-SuissaWeizmann Institute of Science, Department of Neurobiology, Rehovot, Israel.
Oliver HobertDepartment of Biological Sciences, Howard Hughes Medical Institute, Columbia University, New York, United States.ORCID 0000-0002-7634-2854
Howard Hughes Medical Institute · USColumbia University Irving Medical Center · USUniversity of Cologne · DEWeizmann Institute of Science · IL

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Sexually dimorphic regulation of neuronal identity in C.elegansR37NS039996 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HOBERT, OLIVER · 2015 to 2021
$2.5M
Control of sexually dimorphic synaptic wiringF31NS096863 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI BAYER, EMILY A · 2016 to 2018
$132k
Howard Hughes Medical InstituteNIH HHS P40 OD010440NIH HHS R37 NS039996NINDS NIH HHS F31 NS096863NINDS NIH HHS R37 NS039996
6 · The paper itself

Abstract

Sex-specific synaptic connectivity is beginning to emerge as a remarkable, but little explored feature of animal brains. We describe here a novel mechanism that promotes sexually dimorphic neuronal function and synaptic connectivity in the nervous system of the nematode

Indexed as

Caenorhabditis elegans ProteinsSex CharacteristicsTranscription FactorsAnimalsBehavior, AnimalCaenorhabditis elegansDisorders of Sex DevelopmentFemaleGene Knockout TechniquesHumansMaleNeuronsSynaptic TransmissionUbiquitinCaenorhabditis elegans ProteinsTranscription FactorsUbiquitinC. elegansneurosciencesexual dimorphismsynapse pruningtranscription factor

Identifiers

PMID33021200
PMCPMC7538159
OpenAlexW3090097036

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.