ArticleScientific reports2020
Effects of Alzheimer's disease and formalin fixation on the different mineralised-iron forms in the human brain.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Multimodal imaging reveals no evidence for magnetite-based magnetoreceptors in the mole-rat eye.iScience · 2026Article
- Multimodal microscopic and spectroscopic characterisation of heterogeneous iron oxyhydroxides in the human globus pallidus.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
- A Correlative X‑ray Bioimaging Triad for Metals in Biomedical Research.Chemical & biomedical imaging · 2026Review
- Magnetic dipole imaging of magnetite nanoparticles in brain tissue.RSC advances · 2026Article
- Magnetic iron-oxide nanoparticles in the brain connected to alcohol-associated liver disease.Scientific reports · 2025Article
- Air Pollution-Induced Neurotoxicity: The Relationship Between Air Pollution, Epigenetic Changes, and Neurological Disorders.International journal of molecular sciences · 2025Review
- Cortical iron accumulation in MAPT- and C9orf 72-associated frontotemporal lobar degeneration.Brain pathology (Zurich, Switzerland) · 2023Article
- Investigation of brain iron levels in Chinese patients with Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- Radiation as a Tool against Neurodegeneration-A Potential Treatment for Amyloidosis in the Central Nervous System.International journal of molecular sciences · 2022Review
- Role of micronutrients in Alzheimer's disease: Review of available evidence.World journal of clinical cases · 2022Review
- Off-resonance saturation as an MRI method to quantify mineral- iron in the post-mortem brain.Magnetic resonance in medicine · 2022Article
- Histopathological correlates of haemorrhagic lesions onBrain communications · 2022Article
- Iron and Alzheimer's Disease: From Pathology to Imaging.Frontiers in human neuroscience · 2022Review
- Variation in the concentration and regional distribution of magnetic nanoparticles in human brains, with and without Alzheimer's disease, from the UK.Scientific reports · 2021Article
- Effects of fixatives on histomagnetic evaluation of iron in rodent spleen.Journal of magnetism and magnetic materials · 2021Article
- The essential elements of Alzheimer's disease.The Journal of biological chemistryReview
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Iron accumulation in the brain is a phenomenon common to many neurodegenerative diseases, perhaps most notably Alzheimer's disease (AD). We present here magnetic analyses of post-mortem brain tissue of patients who had severe Alzheimer's disease, and compare the results with those from healthy controls. Isothermal remanent magnetization experiments were performed to assess the extent to which different magnetic carriers are affected by AD pathology and formalin fixation. While Alzheimer's brain material did not show higher levels of magnetite/maghemite nanoparticles than corresponding controls, the ferrihydrite mineral, known to be found within the core of ferritin proteins and hemosiderin aggregates, almost doubled in concentration in patients with Alzheimer's pathology, strengthening the conclusions of our previous studies. As part of this study, we also investigated the effects of sample preparation, by performing experiments on frozen tissue as well as tissue which had been fixed in formalin for a period of 5 months. Our results showed that the two different preparations did not critically affect the concentration of magnetic carriers in brain tissue, as observable by SQUID magnetometry.
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