ArticleScientific reports2020
Mathematical modeling of the cardiovascular autonomic control in healthy subjects during a passive head-up tilt test.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Vital Sign and Biochemical Data Collection Using Non-contact Photoplethysmography and the Comestai Mobile Health App: Protocol for an Observational Study.JMIR research protocols · 2025Article
- Article
- A multiscale predictive digital twin for neurocardiac modulation.The Journal of physiology · 2023Article
- Postural orthostatic tachycardia syndrome explained using a baroreflex response model.Journal of the Royal Society, Interface · 2022Article
- Head hemodynamics and systemic responses during auditory stimulation.Physiological reports · 2022Article
- Association of Cardiac Autonomic Responses with Clinical Outcomes of Myasthenia Gravis: Short-Term Analysis of the Heart-Rate and Blood Pressure Variability.Journal of clinical medicine · 2022Article
- Diagnostic Features and Potential Applications of PPG Signal in Healthcare: A Systematic Review.Healthcare (Basel, Switzerland) · 2022Review
- Directional couplings between the respiration and parasympathetic control of the heart rate during sleep and wakefulness in healthy subjects at different ages.Frontiers in network physiology · 2022Article
- Cardiovascular Response to Posture Changes: Multiscale Modeling andFrontiers in physiology · 2022Article
- Synchronization of the Processes of Autonomic Control of Blood Circulation in Humans Is Different in the Awake State and in Sleep Stages.Frontiers in neuroscience · 2021Article
- Simulating Dynamics of Circulation in the Awake State and Different Stages of Sleep Using Non-autonomous Mathematical Model With Time Delay.Frontiers in physiology · 2020Article
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Authors and funding
10 authors.
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Abstract
A mathematical model is proposed for the autonomic control of cardiovascular system, which takes into account two separated self-exciting sympathetic control loops of heart rate and peripheral vascular tone. The control loops are represented by self-exciting time-delay systems and their tone depends on activity of the aortic, carotid, and lower-body baroreceptors. The model is used to study the dynamics of the adaptive processes that manifest in a healthy cardiovascular system during the passive head-up tilt test. Computer simulation provides continuous observation of the dynamics of the indexes and variables that cannot be measured in the direct experiment, including the noradrenaline concentration in vessel wall and heart muscle, tone of the sympathetic and parasympathetic control, peripheral vascular resistance, and blood pressure. In the supine and upright positions, we estimated the spectral characteristics of the model variables, especially in the low-frequency band, and the original index of total percent of phase synchronization between the low-frequency oscillations in heart rate and blood pressure signals. The model demonstrates good quantitative agreement with the dynamics of the experimentally observed indexes of cardiovascular system that were averaged for 50 healthy subjects.
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