Evidence map›Paper›PMID 33020522›Full record

ArticleScientific reports2020

Saturation transfer difference NMR on the integral trimeric membrane transport protein GltPh determines cooperative substrate binding.

Jenny L Hall, Azmat Sohail, Eurico J Cabrita, Colin Macdonald, Thomas Stockner, Harald H Sitte, Jesus Angulo, Fraser MacMillan

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. A two-step mechanism for sugar translocation.Nature structural & molecular biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Jenny L HallHenry Wellcome Unit for Biological EPR, School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Azmat SohailInstitute of Pharmacology, Medical University of Vienna, Währingerstrasse 13A, 1090, Vienna, Austria.
Eurico J CabritaUCIBIO, Chemistry Department, Faculty of Sciences and Technology, NOVA University of Lisbon, 2829-516, Caparica, Portugal.
Colin MacdonaldHenry Wellcome Unit for Biological EPR, School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Thomas StocknerInstitute of Pharmacology, Medical University of Vienna, Währingerstrasse 13A, 1090, Vienna, Austria.
Harald H SitteInstitute of Pharmacology, Medical University of Vienna, Währingerstrasse 13A, 1090, Vienna, Austria.
Jesus AnguloSchool of Pharmacy, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK.
Fraser MacMillanHenry Wellcome Unit for Biological EPR, School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK. fraser.macmillan@uea.ac.uk.
University of East Anglia · GBMedical University of Vienna · ATUniversidade Nova de Lisboa · PT

Funding

Austrian Science Fund FWF F3506Austrian Science Fund FWF F3524Biotechnology and Biological Sciences Research Council BB/M011216/1Biotechnology and Biological Sciences Research Council BB/P010660/1
6 · The paper itself

Abstract

Saturation-transfer difference (STD) NMR spectroscopy is a fast and versatile method which can be applied for drug-screening purposes, allowing the determination of essential ligand binding affinities (K

Indexed as

Amino Acid Transport SystemsAnimalsAspartic AcidBiological TransportGlutamic AcidHydrogen-Ion ConcentrationKineticsMagnetic Resonance SpectroscopyMammalsMembrane ProteinsMembrane Transport ProteinsProteolipidsPyrococcus horikoshiiSubstrate SpecificityAmino Acid Transport SystemsAspartic AcidGlutamic AcidMembrane ProteinsMembrane Transport ProteinsProteolipidsproteoliposomes

Identifiers

PMID33020522
PMCPMC7536232
OpenAlexW3091537481

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.