Evidence map›Paper›PMID 33020501›Full record

ArticleScientific reports2020

Disruption of NREM sleep and sleep-related spatial memory consolidation in mice lacking adult hippocampal neurogenesis.

D Sippel, J Schwabedal, J C Snyder, C N Oyanedel, S N Bernas, A Garthe, A Tröndle, A Storch, G Kempermann, M D Brandt

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

D SippelInstitute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, 72076, Tübingen, Germany.
J SchwabedalMax Planck Institute for the Physics of Complex Systems, 01187, Dresden, Germany.
J C SnyderDepartment of Neurology, University Hospital, Technische Universität Dresden, 01307, Dresden, Germany.
C N OyanedelInstitute of Medical Psychology and Behavioral Neurobiology, University of Tübingen, 72076, Tübingen, Germany.ORCID http://orcid.org/0000-0002-2853-1167
S N BernasCenter for Regenerative Therapies TU Dresden, 01307, Dresden, Germany.ORCID http://orcid.org/0000-0002-9700-6710
A GartheGerman Center for Neurodegenerative Diseases (DZNE) Dresden, 01307, Dresden, Germany.
A TröndleDepartment of Neurology, University Hospital, Technische Universität Dresden, 01307, Dresden, Germany.
A StorchGerman Center for Neurodegenerative Diseases (DZNE) Rostock, 18147, Rostock, Germany.
G KempermannGerman Center for Neurodegenerative Diseases (DZNE) Dresden, 01307, Dresden, Germany.
M D BrandtDepartment of Neurology, University Hospital, Technische Universität Dresden, 01307, Dresden, Germany. moritz.brandt@ukdd.de.
German Center for Neurodegenerative Diseases · DETechnische Universität Dresden · DEMax Planck Institute for the Physics of Complex Systems · DEUniversity Children's Hospital Tübingen · DEUniversity of Tübingen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular plasticity at the structural level and sleep at the behavioural level are both essential for memory formation. The link between the two is not well understood. A functional connection between adult neurogenesis and hippocampus-dependent memory consolidation during NREM sleep has been hypothesized but not experimentally shown. Here, we present evidence that during a three-day learning session in the Morris water maze task a genetic knockout model of adult neurogenesis (Cyclin D2

Indexed as

AnimalsCyclin D2ElectroencephalographyHippocampusMaze LearningMemory ConsolidationMiceMice, Inbred C57BLNeurogenesisNeuronsPolysomnographySleepSleep, Slow-WaveSleep StagesSpatial MemoryCyclin D2

Identifiers

PMID33020501
PMCPMC7536189
OpenAlexW3090051179

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.