Evidence map›Paper›PMID 33020477›Full record

ArticleNature communications2020

c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis.

Yu Chen Feng, Xiao Ying Liu, Liu Teng, Qiang Ji, Yongyan Wu, Jin Ming Li, Wei Gao, Yuan Yuan Zhang, Ting La, Hessam Tabatabaee and 9 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.

0numbers the graph read from it
0cells of the map it votes in
72citing papers in PubMed
6.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

72 citing papers in PubMed, 125 citations in OpenAlex.

  1. Article
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  7. Review
  8. Ubiquitination in cancer: mechanisms and therapeutic opportunities.Cancer communications (London, England) · 2025
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
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  18. SNORD80-guided 2'-O-methylation stabilizes the lncRNA GAS5 to regulate cellular stress responses.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  19. Article
  20. Article

12 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 7 institutions in 2 countries.

Yu Chen Feng *School of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, 2308, NSW, Australia.ORCID http://orcid.org/0000-0001-5507-8129
Xiao Ying Liu *Translational Research Institute, Henan Provincial People's Hospital and People's Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University, Zhengzhou, 450053, Henan, China.ORCID http://orcid.org/0000-0003-3450-5683
Liu TengTranslational Research Institute, Henan Provincial People's Hospital and People's Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University, Zhengzhou, 450053, Henan, China.
Qiang JiTranslational Research Institute, Henan Provincial People's Hospital and People's Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University, Zhengzhou, 450053, Henan, China.
Yongyan WuDepartment of Otolaryngology, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, the first affiliated hospital, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.ORCID http://orcid.org/0000-0003-1669-3860
Jin Ming LiTranslational Research Institute, Henan Provincial People's Hospital and People's Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University, Zhengzhou, 450053, Henan, China.
Wei GaoDepartment of Otolaryngology, Shanxi Key Laboratory of Otorhinolaryngology Head and Neck Cancer, the first affiliated hospital, Shanxi Medical University, Taiyuan, 030001, Shanxi, China.ORCID http://orcid.org/0000-0001-7836-2851
Yuan Yuan ZhangSchool of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, 2308, NSW, Australia.ORCID http://orcid.org/0000-0001-5851-5128
Ting LaSchool of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, 2308, NSW, Australia.
Hessam TabatabaeeSchool of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, 2308, NSW, Australia.ORCID http://orcid.org/0000-0001-8912-1746
Xu Guang YanSchool of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, 2308, NSW, Australia.ORCID http://orcid.org/0000-0001-5995-8537
M Fairuz B JamaluddinSchool of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, 2308, NSW, Australia.ORCID http://orcid.org/0000-0002-7343-9298
Didi ZhangDepartment of Orthopaedics, John Hunter Hospital, Hunter New England Health, Newcastle, 2305, NSW, Australia.
Su Tang GuoDepartment of Molecular Biology, Shanxi Cancer Hospital and Institute, Taiyuan, 030013, Shanxi, China.
Rodney J ScottSchool of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, 2308, NSW, Australia.ORCID http://orcid.org/0000-0001-7724-3404
Tao LiuChildren's Cancer Institute Australia for Medical Research, University of New South Wales, Sydney, 2750, NSW, Australia.
Rick F ThorneSchool of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, 2308, NSW, Australia.ORCID http://orcid.org/0000-0001-7882-7081
Xu Dong ZhangSchool of Biomedical Sciences and Pharmacy, The University of Newcastle, Newcastle, 2308, NSW, Australia. Xu.Zhang@newcastle.edu.au.ORCID http://orcid.org/0000-0001-9457-8003
Lei JinTranslational Research Institute, Henan Provincial People's Hospital and People's Hospital of Zhengzhou University, Academy of Medical Science, Zhengzhou University, Zhengzhou, 450053, Henan, China. Lei.Jin@newcastle.edu.au.ORCID http://orcid.org/0000-0001-7187-9671
University of Newcastle Australia · AUZhengzhou University · CNShanxi Medical University · CNHenan Provincial People's Hospital · CNJohn Hunter Hospital · AUShanxi Provincial Cancer Hospital · CNUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The functions of the proto-oncoprotein c-Myc and the tumor suppressor p53 in controlling cell survival and proliferation are inextricably linked as "Yin and Yang" partners in normal cells to maintain tissue homeostasis: c-Myc induces the expression of ARF tumor suppressor (p14

Indexed as

CarcinogenesisCarrier ProteinsCell Line, TumorCell SurvivalGene Expression Regulation, NeoplasticHumansNeoplasmsPromoter Regions, GeneticProtein BindingProto-Oncogene Proteins c-mycRNA, Long NoncodingSumoylationTumor Suppressor Protein p53UbiquitinationCarrier ProteinsMYC protein, humanProto-Oncogene Proteins c-mycRNA, Long NoncodingTP53 protein, humanTRIML2 protein, humanTumor Suppressor Protein p53

Identifiers

PMID33020477
PMCPMC7536215
OpenAlexW3090105423

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.