Evidence map›Paper›PMID 33020412›Full record

ArticleInternational journal of molecular sciences2020

Neuroprotective Effects of Chronic Resveratrol Treatment and Exercise Training in the 3xTg-AD Mouse Model of Alzheimer's Disease.

Tom L Broderick, Suhail Rasool, Rongzi Li, Yuxian Zhang, Miranda Anderson, Layla Al-Nakkash, Jeffrey H Plochocki, Thangiah Geetha, Jeganathan Ramesh Babu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed
4.1field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 73 citations in OpenAlex.

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  7. Regulation of autophagy-mediated pathways by diet, physical activity, and sleep in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Tom L BroderickDepartment of Physiology, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USA.
Suhail RasoolDepartment of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL 36849, USA.
Rongzi LiDepartment of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL 36849, USA.
Yuxian ZhangDepartment of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL 36849, USA.
Miranda AndersonLaboratory of Diabetes and Exercise Metabolism, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USA.
Layla Al-NakkashDepartment of Physiology, College of Graduate Studies, Midwestern University, Glendale, AZ 85308, USA.ORCID 0000-0001-9309-6213
Jeffrey H PlochockiDepartment of Medical Education, University of Central Florida, College of Medicine, 6850 Lake Nona Blvd, Orlando, FL 32827, USA.ORCID 0000-0002-9054-2078
Thangiah GeethaDepartment of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL 36849, USA.ORCID 0000-0001-6358-0012
Jeganathan Ramesh BabuDepartment of Nutrition, Dietetics, and Hospitality Management, Auburn University, Auburn, AL 36849, USA.
Auburn University · USMidwestern University · USUniversity of Central Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To date, there is no cure or effective treatment for Alzheimer's disease (AD), a chronic neurodegenerative condition that affects memory, language, and behavior. AD is characterized by neuroinflammation, accumulation of brain amyloid-beta (Aβ) oligomers and neurofibrillary tangles, increased neuronal apoptosis, and loss of synaptic function. Promoting regular exercise and a diet containing polyphenols are effective non-pharmacological approaches that prevent the progression of neurodegenerative diseases. In this study, we measured various conformational toxic species of Aβ and markers of inflammation, apoptosis, endolysosomal degradation, and neuroprotection after 5 months of exercise training (ET), resveratrol (Resv) treatment, or combination treatment in the 3xTg-AD mouse model of AD. Our main results indicate that Resv decreased neuroinflammation and accumulation of Aβ oligomers, increased levels of neurotrophins, synaptic markers, silent information regulator, and decreased markers of apoptosis, autophagy, endolysosomal degradation and ubiquitination in the brains of 3xTg-AD mice. ET improved some markers related to neuroprotection, but when combined with Resv treatment, the benefits achieved were as effective as Resv treatment alone. Our results show that the neuroprotective effects of Resv, ET or Resv and ET are associated with reduced toxicity of Aβ oligomers, suppression of neuronal autophagy, decreased apoptosis, and upregulation of key growth-related proteins.

Indexed as

Physical Conditioning, AnimalAlzheimer DiseaseAnimalsDisease Models, AnimalExerciseHumansMiceNeuroprotective AgentsResveratrolNeuroprotective AgentsResveratrolAlzheimer’s diseaseamyloid-betaapoptosisautophagybrainexerciseneuroinflammationneurotrophinresveratrol

Identifiers

PMID33020412
PMCPMC7582460
OpenAlexW3090327551

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.