Evidence map›Paper›PMID 33020398›Full record

ArticleInternational journal of molecular sciences2020

Pharmacological Inhibition of WEE1 Potentiates the Antitumoral Effect of the

Carmelina Antonella Iannuzzi, Paola Indovina, Iris Maria Forte, Sarah Di Somma, Anna Maria Malfitano, Martina Bruno, Giuseppe Portella, Francesca Pentimalli, Antonio Giordano

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Combination ofCells · 2022
    Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Carmelina Antonella IannuzziCell Biology and Biotherapy Unit, Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, I-80131 Naples, Italy.
Paola IndovinaSbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.
Iris Maria ForteCell Biology and Biotherapy Unit, Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, I-80131 Naples, Italy.ORCID 0000-0001-9490-5844
Sarah Di SommaDipartimento Scienze Mediche Traslazionali, Università di Napoli "Federico II", I-80131 Naples, Italy.
Anna Maria MalfitanoDipartimento Scienze Mediche Traslazionali, Università di Napoli "Federico II", I-80131 Naples, Italy.ORCID 0000-0002-6193-2835
Martina BrunoDepartment of Medical Biotechnologies, University of Siena, I-53100 Siena, Italy.
Giuseppe PortellaDipartimento Scienze Mediche Traslazionali, Università di Napoli "Federico II", I-80131 Naples, Italy.
Francesca PentimalliCell Biology and Biotherapy Unit, Istituto Nazionale Tumori, IRCCS, Fondazione G. Pascale, I-80131 Naples, Italy.ORCID 0000-0003-4740-6801
Antonio GiordanoSbarro Institute for Cancer Research and Molecular Medicine, Center for Biotechnology, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA.ORCID 0000-0002-5959-016X
Istituto Nazionale Tumori IRCCS "Fondazione G. Pascale" · ITUniversity of Naples Federico II · ITUniversity of Siena · ITInstitute for High Performance Computing and Networking · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant mesothelioma (MM) is a very aggressive asbestos-related cancer, for which no therapy proves to be effective. We have recently shown that the oncolytic adenovirus

Indexed as

AdenoviridaeApoptosisAsbestosCell Cycle ProteinsCell Line, TumorCell SurvivalDNA DamageHumansMesothelioma, MalignantOncolytic VirotherapyOncolytic VirusesPhosphorylationProtein Kinase InhibitorsProtein-Tyrosine KinasesPyrazolesPyrimidinonesadavosertibAsbestosCell Cycle ProteinsProtein Kinase InhibitorsProtein-Tyrosine KinasesPyrazolesPyrimidinonesWEE1 protein, humanadavosertibapoptosisAZD1775dl922-947DNA damage responseG2/M checkpointmalignant mesotheliomaMK-1775oncolytic adenovirusWEE1

Identifiers

PMID33020398
PMCPMC7582744
OpenAlexW3090467634

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.