Evidence map›Paper›PMID 33020241›Full record

ArticleJournal for immunotherapy of cancer2020

Elly L van der Veen, Danique Giesen, Linda Pot-de Jong, Annelies Jorritsma-Smit, Elisabeth G E De Vries, Marjolijn N Lub-de Hooge

Open access · goldAbstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.

  1. Pooled it
  2. Challenges in tracer development for tumor microenvironment (TME) imaging.European journal of nuclear medicine and molecular imaging · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Hepatocellular Carcinoma Around the Clock.Current oncology (Toronto, Ont.) · 2026
    Review
  7. Review
  8. Review
  9. Article
  10. 3'-deoxy-3'-EJNMMI research · 2025
    Article
  11. Article
  12. Review
  13. New Long-Acting [Journal of medicinal chemistry · 2023
    Article
  14. Evaluation ofACS omega · 2023
    Article
  15. Review
  16. Development of Radiotracers for Imaging of the PD-1/PD-L1 Axis.Pharmaceuticals (Basel, Switzerland) · 2022
    Review
  17. Article
  18. Immuno-Imaging (PET/SPECT)-Quo Vadis?Molecules (Basel, Switzerland) · 2022
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Elly L van der VeenDepartment of Medical Oncology, UMCG, Groningen, Groningen, Netherlands.ORCID 0000-0001-6224-8114
Danique GiesenDepartment of Medical Oncology, UMCG, Groningen, Groningen, Netherlands.
Linda Pot-de JongDepartment of Medical Oncology, UMCG, Groningen, Groningen, Netherlands.
Annelies Jorritsma-SmitDepartment of Clinical Pharmacy and Pharmacology, UMCG, Groningen, Groningen, Netherlands.
Elisabeth G E De VriesDepartment of Medical Oncology, UMCG, Groningen, Groningen, Netherlands.
Marjolijn N Lub-de HoogeDepartment of Clinical Pharmacy and Pharmacology, UMCG, Groningen, Groningen, Netherlands m.n.de.hooge@umcg.nl.ORCID 0000-0002-5390-2791
University Medical Center Groningen · NLDialyse Centrum Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo better predict response to immune checkpoint therapy and toxicity in healthy tissues, insight in the in vivo behavior of immune checkpoint targeting monoclonal antibodies is essential. Therefore, we aimed to study in vivo pharmacokinetics and whole-body distribution of zirconium-89 (

methodsHumanized (huNOG) and non-humanized NOG mice were xenografted with human A375M melanoma cells. PET imaging was performed on day 7 post

resultsPET imaging and biodistribution studies showed high

conclusion

Indexed as

AnimalsAntibodies, Monoclonal, HumanizedAntineoplastic Agents, ImmunologicalBiomarkers, TumorCell Line, TumorHumansImmunotherapyMiceProgrammed Cell Death 1 ReceptorTertiary Lymphoid StructuresAntibodies, Monoclonal, HumanizedAntineoplastic Agents, ImmunologicalBiomarkers, TumorPdcd1 protein, mousepembrolizumabProgrammed Cell Death 1 ReceptorimmunotherapyT-lymphocytestumor biomarkers

Identifiers

PMID33020241
PMCPMC7537332
OpenAlexW3090847941

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.