Evidence map›Paper›PMID 33020220›Full record

ArticleJournal of bacteriology2020

c-di-AMP Accumulation Impairs Muropeptide Synthesis in Listeria monocytogenes.

Steven M Massa, Amar Deep Sharma, Cheta Siletti, Zepeng Tu, Jared J Godfrey, William G Gutheil, TuAnh N Huynh

Open access · greenAbstract read
In one paragraph

Article in Journal of bacteriology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 32 citations in OpenAlex.

  1. Mislocalization of PBPs inMicrobiology spectrum · 2026
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  5. The role ofJournal of bacteriology · 2024
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  9. Review
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  12. c-di-AMP Is Essential for the Virulence ofInfection and immunity · 2021
    Article
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  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Steven M MassaFood Science Department, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Amar Deep SharmaDivision of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, Missouri, USA.
Cheta SilettiMicrobiology Doctoral Training Program, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Zepeng TuFood Science Department, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Jared J GodfreyFood Science Department, University of Wisconsin-Madison, Madison, Wisconsin, USA.
William G GutheilDivision of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of Missouri-Kansas City, Kansas City, Missouri, USA.
TuAnh N HuynhFood Science Department, University of Wisconsin-Madison, Madison, Wisconsin, USA thuynh6@wisc.edu.ORCID 0000-0002-7313-6166
University of Wisconsin–Madison · USUniversity of Missouri–Kansas City · US

Funding

VRE Regulation and InhibitionR15GM126502 · NIGMS · UNIVERSITY OF MISSOURI KANSAS CITY · PI GUTHEIL, WILLIAM G · 2018 to 2018
$465k
NIGMS NIH HHS R15 GM126502
6 · The paper itself

Abstract

Cyclic di-AMP (c-di-AMP) is an essential and ubiquitous second messenger among bacteria. c-di-AMP regulates many cellular pathways through direct binding to several molecular targets in bacterial cells. c-di-AMP depletion is well known to destabilize the bacterial cell wall, resulting in increased bacteriolysis and enhanced susceptibility to cell wall targeting antibiotics. Using the human pathogen

Indexed as

Bacterial ProteinsCell WallCyclic AMPGene Expression Regulation, BacterialHumansListeria monocytogenesListeriosisPeptidesPhosphoric Diester HydrolasesPotassiumSecond Messenger SystemsBacterial ProteinsCyclic AMPPeptidesPhosphoric Diester HydrolasesPotassiumc-di-AMPListeria monocytogenespeptidoglycan

Identifiers

PMID33020220
PMCPMC7685554
OpenAlexW3089601869

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.