ArticleESMO open2020
Prognostic factors in phyllodes tumours of the breast: retrospective study on 166 consecutive cases.
Article in ESMO open, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 31 citations in OpenAlex.
- Optimal surgical margin and the efficacy of adjuvant radiotherapy in borderline and malignant phyllodes tumors: a multicenter retrospective study.Radiation oncology journal · 2026Article
- Risk Stratification of Fibroepithelial Breast Lesions: Clinical and Ultrasound Features Associated with Fibroadenoma and Phyllodes Tumors.Annals of surgical oncology · 2026Article
- AI-FLEET: Phase I-Multimodal Deep Learning Model for Phyllodes Tumor Classification.Annals of surgical oncology · 2026Article
- The impact of different pathological diagnostic criteria on the prognosis of malignant phyllodes tumors of the breast.Virchows Archiv : an international journal of pathology · 2026Article
- Tumor Growth Rate Predicts Pathological Outcomes in Breast Fibroepithelial Tumors: A Pilot Study and Review of Literature.Cancers · 2026Article
- Malignant phyllodes tumor of the breast with heterologous osteosarcomatous and pleomorphic liposarcomatous differentiation: a rare case report and literature review.Frontiers in oncology · 2026Article
- Malignant Phyllodes Tumor in Adolescent Females: A Report of Three Cases and Review of the Literature.Case reports in surgery · 2026Article
- Case Report: Coexistence of a giant borderline phyllodes tumor of the breast and a contralateral fibroadenoma: a challenging case with clinical manifestations and PET-CT imaging mimicking advanced cancer.Frontiers in oncology · 2026Article
- Complete Remission of Metastatic Osteosarcoma From a Breast Malignant Phyllodes Tumor: A Case Report.Journal of breast cancer · 2025Article
- A Multidisciplinary Perspective on Breast Phyllodes Tumors: A Literature Review.Medicina (Kaunas, Lithuania) · 2025Review
- Clinicopathological characteristics and outcomes of phyllodes tumors in a tertiary care center: a retrospective study.Gland surgery · 2025Article
- Malignant phyllodes tumours of the breast: the case for revising WHO's 'full house' diagnostic criteria.Histopathology · 2025Review
- The pathologic and genomic evolution of primary malignant phyllodes tumors of the breast: retrospective cohort study and case-control genomic analysis.The oncologist · 2025Article
- Borderline Phyllodes Breast Tumors: A Comprehensive Review of Recurrence, Histopathological Characteristics, and Treatment Modalities.Current oncology (Toronto, Ont.) · 2025Review
- Expression patterns of H3K27me3 for differentiation of breast fibroadenomas and phyllodes tumors.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2025Article
- Management of malignant breast phyllodes tumor with rib invasion during pregnancy: a rare case report and literature review.Frontiers in oncology · 2025Article
- Postoperative surgical margin results of the phyllodes tumors from a tertiary hospital.Revista da Associacao Medica Brasileira (1992) · 2024Article
- Article
- Prognostic factors of breast phyllodes tumors.Histology and histopathology · 2023Review
- Predicting the recurrence-free survival of phyllodes tumor of the breast: a nomogram based on clinicopathology features, treatment, and surgical margin.Gland surgery · 2023Article
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Authors and funding
17 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPhyllodes tumours (PTs) are rare fibroepithelial tumours accounting for <1% of all breast tumours. We assessed clinicopathological features and their prognostic effect in a single-institution patients' cohort.
methodsPatients diagnosed with PT between 2001 and 2018 at our institution were identified. Clinical, surgical and pathological features were collected. Phyllodes-related relapse was defined as locoregional or distant recurrence (contralateral excluded), whichever first.
resultsA total of 166 patients were included: 115 with benign, 30 with borderline and 21 with malignant PTs. Features associated with malignant PT were younger age, larger T size, higher mitotic count, marked cytological atypia, stromal overgrowth, stromal hypercellularity, necrosis and heterologous differentiation (all p<0.01). The majority of patients with malignant PT underwent mastectomy (63.2% vs 3% of benign/borderline, p<0.001) and had negative surgical margins (83.3%). 4-year cumulative phyllodes-related relapse incidence was 7% for benign/borderline PT and 21.3% for malignant PT (p=0.107). In the entire cohort, marked cellular atypia and heterologous differentiation were associated with worse phyllodes-related relapse-free survival (HR 14.10, p=0.036 for marked vs mild atypia; HR 4.21, p=0.031 for heterologous differentiation present vs absent). For patients with benign PT, larger tumour size was associated with worse phyllodes-related relapse-free survival (HR 9.67, p=0.013 for T>5 cm vs T≤2 cm). Higher tumour-infiltrating lymphocytes (TILs) were associated with borderline and malignant PT (p=0.023); TILs were not associated with phyllodes-related relapse-free survival (HR 0.58, p=0.361 for TILs>2% vs≤2%). Overall, four patients died because of PT: three patients with malignant and one with borderline PT.
conclusionsPatients with malignant PT had increased rates of phyllodes-related relapse and phyllodes-related death. Cellular atypia and heterologous differentiation were poor prognostic factors in the entire cohort; large tumour size was associated with an increased risk of phyllodes-related relapse in benign PT.
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