Evidence map›Paper›PMID 33020216›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2020

Altered Outer Hair Cell Mitochondrial and Subsurface Cisternae Connectomics Are Candidate Mechanisms for Hearing Loss in Mice.

Guy Perkins, Jeong Han Lee, Seojin Park, Mincheol Kang, Maria C Perez-Flores, Saeyeon Ju, Grady Phillips, Anna Lysakowski, Michael Anne Gratton, Ebenezer N Yamoah

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. SKOOTS: Skeleton-oriented object segmentation for mitochondria.bioRxiv : the preprint server for biology · 2025
    Article
  3. Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  4. Article
  5. Review
  6. Mitochondrial morphology governs ATP production rate.The Journal of general physiology · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Peripheral Auditory Nerve Impairment in a Mouse Model of Syndromic Autism.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  14. Morphological principles of neuronal mitochondria.The Journal of comparative neurology · 2022
    Article
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Guy PerkinsNational Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, California 92093.
Jeong Han LeeUniversity of Nevada, Reno, Nevada 89557.
Seojin ParkUniversity of Nevada, Reno, Nevada 89557.
Mincheol KangUniversity of Nevada, Reno, Nevada 89557.
Maria C Perez-FloresUniversity of Nevada, Reno, Nevada 89557.
Saeyeon JuNational Center for Microscopy and Imaging Research, University of California, San Diego, La Jolla, California 92093.
Grady PhillipsWashington University School of Medicine, St. Louis, Missouri 63110.
Anna LysakowskiDepartments of Anatomy and Cell Biology and Otolaryngology, University of Illinois at Chicago, Chicago, Illinois 60612.ORCID 0000-0001-6259-0294
Michael Anne GrattonWashington University School of Medicine, St. Louis, Missouri 63110.
Ebenezer N YamoahUniversity of Nevada, Reno, Nevada 89557 enyamoah@gmail.com.ORCID 0000-0002-9797-085X
University of Nevada, Reno · USUniversity of California San Diego · USWashington University in St. Louis · USUniversity of Illinois Chicago · US

Funding

VOLUMETRIC CONTOUR-BASED SURFACE RECONSTRUCTIONP41RR004050 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI AKASSOGLOU, KATERINA · 1989 to 2011
$28.0M
IVEM and Image Analysis ResourceP41GM103412 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2012 to 2019
$17.9M
Structural Analyses CoreP01AG051443 · NIA · UNIVERSITY OF NEVADA RENO · PI YAMOAH, EBENEZER N · 2016 to 2025
$15.5M
Inner ear ion channels in healthy and diseased conditionsR01DC016099 · NIDCD · UNIVERSITY OF NEVADA RENO · PI EBENEZER N YAMOAH · 2017 to 2026
$4.7M
The National Center for Microscopy and Imaging Research, a Community-wide Scientific ResourceR24GM137200 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ELLISMAN, MARK H · 2020 to 2022
$3.0M
Mechanisms of Growth Factor Responsiveness in the Aging Auditory SystemR01AG060504 · NIA · UNIVERSITY OF NEVADA RENO · PI FRITZSCH, BERND, YAMOAH, EBENEZER N · 2018 to 2022
$2.5M
Calcium-dependent functions in Hair Cells and Spiral Ganglion NeuronsR01DC015135 · NIDCD · UNIVERSITY OF NEVADA RENO · PI GRATTON, MICHAEL ANNE NMI, YAMOAH, EBENEZER N · 2016 to 2020
$2.1M
Mitochondrial structure and non-syndromic and aminoglycoside-related deafnessR21DC013181 · NIDCD · UNIVERSITY OF ILLINOIS AT CHICAGO · PI LYSAKOWSKI, ANNA · 2014 to 2015
$461k
NCRR NIH HHS P41 RR004050NIA NIH HHS P01 AG051443NIA NIH HHS R01 AG060504NIDCD NIH HHS R01 DC015135NIDCD NIH HHS R01 DC016099NIDCD NIH HHS R21 DC013181NIGMS NIH HHS P41 GM103412NIGMS NIH HHS R24 GM137200
6 · The paper itself

Abstract

Organelle crosstalk is vital for cellular functions. The propinquity of mitochondria, ER, and plasma membrane promote regulation of multiple functions, which include intracellular Ca

Indexed as

Adenosine TriphosphateAgingAnimalsCalciumConnectomeCytoplasmEndoplasmic ReticulumEnergy MetabolismEvoked Potentials, Auditory, Brain StemFemaleHair Cells, Auditory, OuterHearing LossMaleMembrane Potential, MitochondrialMiceMitochondriaAdenosine TriphosphateCalciumPotassiumcalcium homeostasisdeafnesshearing lossinner earmitochondriaouter hair cells

Identifiers

PMID33020216
PMCPMC7605424
OpenAlexW3090310282

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.