Evidence map›Paper›PMID 33020157›Full record

ArticleAntimicrobial agents and chemotherapy2020

KPC Beta-Lactamases Are Permissive to Insertions and Deletions Conferring Substrate Spectrum Modifications and Resistance to Ceftazidime-Avibactam.

Claire Amaris Hobson, Stéphane Bonacorsi, Hervé Jacquier, Alaksh Choudhury, Mélanie Magnan, Aurélie Cointe, Béatrice Bercot, Olivier Tenaillon, André Birgy

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 44 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Enhanced Spread of Carbapenem-ResistantInfection and drug resistance · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Evolution of ceftazidime-avibactam resistance driven by variation inFrontiers in cellular and infection microbiology · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. KPC-2 allelic variants inMicrobiology spectrum · 2024
    Article
  14. Multidrug Resistant Enteric Bacteria from Cancer Patients Admitted in Douala Laquintinie Hospital, Littoral Region of Cameroon.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2024
    Article
  15. Resistance to aztreonam-avibactam due to a mutation of SHV-12 in Enterobacter.Annals of clinical microbiology and antimicrobials · 2023
    Article
  16. Article
  17. A comparative study of intestinalOne health advances · 2023
    Article
  18. Review
  19. Review
  20. The interplay between anticancer challenges and the microbial communities from the gut.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Claire Amaris HobsonIAME, UMR 1137, INSERM, Université de Paris, AP-HP, Paris, France.
Stéphane BonacorsiIAME, UMR 1137, INSERM, Université de Paris, AP-HP, Paris, France.
Hervé JacquierIAME, UMR 1137, INSERM, Université de Paris, AP-HP, Paris, France.
Alaksh ChoudhuryIAME, UMR 1137, INSERM, Université de Paris, AP-HP, Paris, France.
Mélanie MagnanIAME, UMR 1137, INSERM, Université de Paris, AP-HP, Paris, France.
Aurélie CointeIAME, UMR 1137, INSERM, Université de Paris, AP-HP, Paris, France.
Béatrice BercotIAME, UMR 1137, INSERM, Université de Paris, AP-HP, Paris, France.ORCID 0000-0003-1603-3635
Olivier TenaillonIAME, UMR 1137, INSERM, Université de Paris, AP-HP, Paris, France.
André BirgyIAME, UMR 1137, INSERM, Université de Paris, AP-HP, Paris, France andre.birgy@aphp.fr.ORCID 0000-0001-9462-0582
Inserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To explore the mutational possibilities of insertions and deletions (indels) in the

Indexed as

Azabicyclo CompoundsCeftazidimeKlebsiella InfectionsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasesDrug CombinationsHumansKlebsiella pneumoniaeMicrobial Sensitivity TestsAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo CompoundsBacterial Proteinsbeta-LactamasescarbapenemaseCeftazidimeDrug Combinationscarbapenemaseceftazidime-avibactamdeletionhydrolysis spectruminsertionKPCmutationmutational toleranceomega loop

Identifiers

PMID33020157
PMCPMC7674030
OpenAlexW3091303527

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.