Evidence map›Paper›PMID 33020152›Full record

ArticleAntimicrobial agents and chemotherapy2020

Associations between Malaria-Preventive Regimens and Plasmodium falciparum Drug Resistance-Mediating Polymorphisms in Ugandan Pregnant Women.

Patience Nayebare, Victor Asua, Melissa D Conrad, Richard Kajubi, Abel Kakuru, Joaniter I Nankabirwa, Dennis Muhanguzi, Grant Dorsey, Moses R Kamya, Sam Nsobya and 1 more

Open access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  6. RecurrentmedRxiv : the preprint server for health sciences · 2025
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  14. Multi-Omics Advancements towardsDiagnostics (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Patience NayebareInfectious Diseases Research Collaboration, Kampala, Uganda.
Victor AsuaInfectious Diseases Research Collaboration, Kampala, Uganda.ORCID 0000-0002-0489-4692
Melissa D ConradDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-9984-8030
Richard KajubiInfectious Diseases Research Collaboration, Kampala, Uganda.
Abel KakuruInfectious Diseases Research Collaboration, Kampala, Uganda.
Joaniter I NankabirwaInfectious Diseases Research Collaboration, Kampala, Uganda.
Dennis MuhanguziCollege of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, Kampala, Uganda.
Grant DorseyDepartment of Medicine, University of California San Francisco, San Francisco, California, USA.
Moses R KamyaInfectious Diseases Research Collaboration, Kampala, Uganda.
Sam NsobyaInfectious Diseases Research Collaboration, Kampala, Uganda.
Philip J RosenthalDepartment of Medicine, University of California San Francisco, San Francisco, California, USA philip.rosenthal@ucsf.edu.ORCID 0000-0002-7953-7622
Infectious Diseases Research Collaboration · UGUniversity of California, San Francisco · USMakerere University · UG

Funding

Transmission ProjectU19AI089674 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MATTHEW G DORSEY, MOSES Robert KAMYA · 2010 to 2026
$29.3M
The immunologic consequences of prenatal exposure to malariaP01HD059454 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DORSEY, MATTHEW G · 2008 to 2017
$22.6M
UCSF Nutrition Obesity Research CenterP30DK098722 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHRISTIAN VAISSE · 2015 to 2026
$14.6M
Resistance of Malaria Parasites to Artemisinin-Based TherapiesR01AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2009 to 2024
$8.4M
The impact of antimalarials and insecticide resistance on malaria transmission in UgandaK01TW010868 · FIC · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CONRAD, MELISSA D · 2018 to 2022
$706k
Resistance of Malaria Parasites to Artemisinin-Based Combination TherapiesR56AI075045 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROSENTHAL, PHILIP JON · 2008 to 2008
$618k
Impact of malaria control interventions on the infectious reservoir, host immunity, and drug resistance in UgandaK43TW010365 · FIC · INFECTIOUS DISEASES RES COLLABORATION · PI NANKABIRWA, JOANITER IMMACULATE · 2017 to 2021
$514k
FIC NIH HHS K01 TW010868FIC NIH HHS K43 TW010365NIAID NIH HHS R01 AI075045NIAID NIH HHS R56 AI075045NIAID NIH HHS U19 AI089674NICHD NIH HHS P01 HD059454NIDDK NIH HHS P30 DK098722
6 · The paper itself

Abstract

Intermittent preventive treatment in pregnancy (IPTp) with monthly sulfadoxine-pyrimethamine (SP) is recommended for malaria-endemic parts of Africa, but efficacy is compromised by resistance, and, in recent trials, dihydroartemisinin-piperaquine (DP) has shown better antimalarial protective efficacy. We utilized blood samples from a recent trial to evaluate selection by IPTp with DP or SP of

Indexed as

AntimalarialsMalariaMalaria, FalciparumPlasmodium falciparumDrug CombinationsDrug ResistanceFemaleHumansPolymorphism, GeneticPregnancyPregnant PeoplePyrimethamineSulfadoxineUgandaAntimalarialsDrug CombinationsPyrimethamineSulfadoxinedihydroartemisinin-piperaquineintermittent preventive therapymalariaPlasmodium falciparumsulfadoxine-pyrimethamine

Identifiers

PMID33020152
PMCPMC7674052
OpenAlexW3091148990

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.