Evidence map›Paper›PMID 33020148›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2020

Notch Regulates Innate Lymphoid Cell Plasticity during Human NK Cell Development.

Ansel P Nalin, Jesse J Kowalski, Alexander C Sprague, Blaire K Schumacher, Adam G Gerhardt, Youssef Youssef, Kiran V Vedantam, Xiaoli Zhang, Christian W Siebel, Emily M Mace and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Quantifying Human Natural Killer Cell Migration by Imaging and Image Analysis.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. EfficientFrontiers in immunology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Ansel P NalinComprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.ORCID 0000-0001-5673-0203
Jesse J KowalskiComprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.
Alexander C SpragueComprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.ORCID 0000-0003-0880-6298
Blaire K SchumacherComprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.ORCID 0000-0003-1915-1899
Adam G GerhardtComprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.ORCID 0000-0001-9965-3914
Youssef YoussefComprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.
Kiran V VedantamComprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.
Xiaoli ZhangComprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.
Christian W SiebelDepartment of Molecular Biology, Genentech Inc., South San Francisco, CA 94080.
Emily M MaceDepartment of Pediatrics, Columbia University, New York, NY 10032.
Michael A CaligiuriDepartment of Hematology and Hematopoietic Cell Transplantation, City of Hope National Medical Center, Duarte, CA 91010; and.ORCID 0000-0002-4095-3020
Bethany L Mundy-BosseComprehensive Cancer Center, The Ohio State University, Columbus, OH 43210.
Aharon G FreudComprehensive Cancer Center, The Ohio State University, Columbus, OH 43210; aharon.freud@osumc.edu.ORCID 0000-0001-6086-1521
The Ohio State University · USCity Of Hope National Medical Center · USColumbia University · USGene Therapy Laboratory · FR

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Human natural killer cells: Advancing biology and clinical applicationsR35CA210087 · NCI · OHIO STATE UNIVERSITY · PI MICHAEL A CALIGIURI · 2017 to 2026
$8.3M
IL-15--CHARACTERIZATION THROUGH EXPERIMENTAL IMMUNOLOGYR01CA068458 · NCI · ROSWELL PARK CANCER INSTITUTE · PI CALIGIURI, MICHAEL A, YU, JIANHUA · 1996 to 2019
$4.5M
Elucidation of Human Natural Killer Cell DevelopmentR01CA208353 · NCI · OHIO STATE UNIVERSITY · PI AHARON G FREUD · 2017 to 2026
$4.0M
DEFINING THE ROLE OF CELL MIGRATION IN HUMAN NK CELL DIFFERENTIATIONR01AI137073 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MACE, EMILY MARGARET · 2018 to 2022
$2.0M
IL-15 characterization through experimental immunologyR37CA068458 · NCI · OHIO STATE UNIVERSITY · PI CALIGIURI, MICHAEL A · 2010 to 2014
$1.4M
The role of Notch signaling in human natural killer cell functional maturationF30CA236063 · NCI · OHIO STATE UNIVERSITY · PI NALIN, ANSEL PETER · 2019 to 2020
$79k
NCI NIH HHS F30 CA236063NCI NIH HHS L30 CA199447NCI NIH HHS P30 CA016058NCI NIH HHS R01 CA068458NCI NIH HHS R01 CA208353NCI NIH HHS R35 CA210087NCI NIH HHS R37 CA068458NIAID NIH HHS R01 AI137073
6 · The paper itself

Abstract

Human NK cells develop in tonsils through discrete NK cell developmental intermediates (NKDIs), yet the mechanistic regulation of this process is unclear. We demonstrate that Notch activation in human tonsil-derived stage 3 (CD34

Indexed as

Cell DifferentiationCell PlasticityCells, CulturedHumansImmunity, InnateKiller Cells, NaturalLectins, C-TypePalatine TonsilPrimary Cell CultureReceptor, Notch1Receptor, Notch2Receptors, Natural Killer CellSignal TransductionKLRF1 protein, humanLectins, C-TypeNOTCH1 protein, humanNOTCH2 protein, humanReceptor, Notch1Receptor, Notch2Receptors, Natural Killer Cell

Identifiers

PMID33020148
PMCPMC7658047
OpenAlexW3089872036

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.