Evidence map›Paper›PMID 33020143›Full record

ArticleMolecular pharmacology2020

Allosterically Potentiated

Douglas R Miller, Habibeh Khoshbouei, Sumanta Garai, Lucas N Cantwell, Clare Stokes, Ganesh Thakur, Roger L Papke

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Differential Activation and Desensitization States Promoted by NoncanonicalThe Journal of pharmacology and experimental therapeutics · 2022
    Article
  7. Review
  8. Stable desensitization of αEuropean journal of pharmacology · 2021
    Article
  9. Therapeutic Targeting ofPharmacological reviews · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Douglas R MillerDepartments of Neuroscience (D.R.M., H.K.) and Pharmacology and Therapeutics (C.S., R.L.P.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., L.N.C., G.T.).
Habibeh KhoshboueiDepartments of Neuroscience (D.R.M., H.K.) and Pharmacology and Therapeutics (C.S., R.L.P.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., L.N.C., G.T.).
Sumanta GaraiDepartments of Neuroscience (D.R.M., H.K.) and Pharmacology and Therapeutics (C.S., R.L.P.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., L.N.C., G.T.).
Lucas N CantwellDepartments of Neuroscience (D.R.M., H.K.) and Pharmacology and Therapeutics (C.S., R.L.P.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., L.N.C., G.T.).
Clare StokesDepartments of Neuroscience (D.R.M., H.K.) and Pharmacology and Therapeutics (C.S., R.L.P.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., L.N.C., G.T.).
Ganesh ThakurDepartments of Neuroscience (D.R.M., H.K.) and Pharmacology and Therapeutics (C.S., R.L.P.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., L.N.C., G.T.).
Roger L PapkeDepartments of Neuroscience (D.R.M., H.K.) and Pharmacology and Therapeutics (C.S., R.L.P.), University of Florida, Gainesville, Florida; and Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, Massachusetts (S.G., L.N.C., G.T.) rlpapke@ufl.edu.
University of Florida · USNortheastern University · US

Funding

Targeting of Alpha7 nAChR for therapeutic effectsR01GM057481 · NIGMS · UNIVERSITY OF FLORIDA · PI PAPKE, ROGER L · 2000 to 2023
$7.6M
Alpha-synuclein Regulates Dopamine Transporter FunctionsR01NS071122 · NINDS · UNIVERSITY OF FLORIDA · PI KHOSHBOUEI, HABIBEH · 2010 to 2022
$3.9M
Methamphetamine regulates the dopamine transporter via an intracellular mechanismR01DA026947 · NIDA · UNIVERSITY OF FLORIDA · PI KHOSHBOUEI, HABIBEH · 2010 to 2019
$3.5M
A Novel Pharmacotherapy for GlaucomaR01EY024717 · NEI · NORTHEASTERN UNIVERSITY · PI THAKUR, GANESH A · 2014 to 2018
$2.2M
NEI NIH HHS R01 EY024717NIDA NIH HHS R01 DA026947NIGMS NIH HHS R01 GM057481NINDS NIH HHS R01 NS071122
6 · The paper itself

Abstract

The currents of

Indexed as

AcetylcholineAllosteric RegulationAllosteric Sitealpha7 Nicotinic Acetylcholine ReceptorAnimalsCalciumCell Membrane PermeabilityHEK293 CellsHumansOocytesPatch-Clamp TechniquesPhenylpropionatesPiperazinesQuinolinesSulfonamidesXenopus laevis4-(4-bromophenyl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinoline-8-sulfonamideAcetylcholinealpha7 Nicotinic Acetylcholine ReceptorB-973 compoundCalciumPhenylpropionatesPiperazinesQuinolinesSulfonamides

Identifiers

PMID33020143
PMCPMC7662531
OpenAlexW3091329945

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.