Evidence map›Paper›PMID 33020066›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2020

Site-Directed Mutagenesis at the Molybdenum Pterin Cofactor Site of the Human Aldehyde Oxidase: Interrogating the Kinetic Differences Between Human and Cynomolgus Monkey.

Armina Abbasi, Carolyn A Joswig-Jones, Jeffrey P Jones

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Armina AbbasiDepartment of Chemistry, Washington State University, Pullman, Washington.
Carolyn A Joswig-JonesDepartment of Chemistry, Washington State University, Pullman, Washington.
Jeffrey P JonesDepartment of Chemistry, Washington State University, Pullman, Washington jpj@wsu.edu.
Washington State University · US

Funding

Understanding the Metabolic Impact of Aldehyde Oxidase on New Drug DesignR01GM100874 · NIGMS · WASHINGTON STATE UNIVERSITY · PI JONES, JEFFREY P · 2012 to 2019
$2.6M
NIGMS NIH HHS R01 GM100874
6 · The paper itself

Abstract

The estimation of the drug clearance by aldehyde oxidase (AO) has been complicated because of this enzyme's atypical kinetics and species and substrate specificity. Since human AO (hAO) and cynomolgus monkey AO (mAO) have a 95.1% sequence identity, cynomolgus monkeys may be the best species for estimating AO clearance in humans. Here, O

Indexed as

Aldehyde OxidaseAnimalsCoenzymesDantroleneDrug Evaluation, PreclinicalGuanineMacaca fascicularisMetalloproteinsMolybdenum CofactorsMutagenesis, Site-DirectedOxidation-ReductionPteridinesSequence Homology, Amino AcidSpecies SpecificitySubstrate SpecificityAldehyde OxidaseAOX1 protein, humanCoenzymesDantroleneGuanineMetalloproteinsMolybdenum CofactorsmolybdopterinO(6)-benzylguaninePteridines

Identifiers

PMID33020066
PMCPMC7718725
OpenAlexW3089730004

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.