Evidence map›Paper›PMID 33020065›Full record

ArticleDrug metabolism and disposition: the biological fate of chemicals2020

Cell Type-Specific Roles of CD38 in the Interactions of Isoniazid with NAD

Junjie Zhu, Jie Lu, Hung-Chun Tung, Ke Liu, Jianhua Li, Denis M Grant, Wen Xie, Xiaochao Ma

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug metabolism and disposition: the biological fate of chemicals, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Roles of Cofactors in Drug-Induced Liver Injury: Drug Metabolism and Beyond.Drug metabolism and disposition: the biological fate of chemicals · 2022
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Junjie ZhuCenter for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (J.Z., J.L., H.-C.T., K.L., J.L., W.X., X.M.) and Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (D.M.G.).
Jie LuCenter for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (J.Z., J.L., H.-C.T., K.L., J.L., W.X., X.M.) and Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (D.M.G.).
Hung-Chun TungCenter for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (J.Z., J.L., H.-C.T., K.L., J.L., W.X., X.M.) and Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (D.M.G.).
Ke LiuCenter for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (J.Z., J.L., H.-C.T., K.L., J.L., W.X., X.M.) and Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (D.M.G.).
Jianhua LiCenter for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (J.Z., J.L., H.-C.T., K.L., J.L., W.X., X.M.) and Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (D.M.G.).
Denis M GrantCenter for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (J.Z., J.L., H.-C.T., K.L., J.L., W.X., X.M.) and Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (D.M.G.).
Wen XieCenter for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (J.Z., J.L., H.-C.T., K.L., J.L., W.X., X.M.) and Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (D.M.G.).
Xiaochao MaCenter for Pharmacogenetics, Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (J.Z., J.L., H.-C.T., K.L., J.L., W.X., X.M.) and Department of Pharmacology and Toxicology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada (D.M.G.) mxiaocha@pitt.edu.
University of Toronto · CAUniversity of Pittsburgh · US

Funding

Pharmacoenhancers for antiretroviral therapy: safety and future developmentR01AI131983 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MA, XIAOCHAO · 2017 to 2021
$1.9M
Preclinical screening and validation for PXR-mediated herb-drug interactions associated with anti-HIV therapyR21AT011088 · NCCIH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MA, XIAOCHAO · 2020 to 2021
$421k
NCCIH NIH HHS R21 AT011088NIAID NIH HHS R01 AI131983
6 · The paper itself

Abstract

NAD

Indexed as

ADP-ribosyl Cyclase 1AnimalsAntitubercular AgentsArylamine N-AcetyltransferaseCells, CulturedHepatic Stellate CellsIsoenzymesIsoniazidKupffer CellsLiverMaleMiceMice, KnockoutModels, AnimalNADPrimary Cell CultureacetylisoniazidADP-ribosyl Cyclase 1Antitubercular AgentsArylamine N-AcetyltransferaseIsoenzymesIsoniazidN-acetyltransferase 1NADNat2 enzyme, mouse

Identifiers

PMID33020065
PMCPMC7718729
OpenAlexW3090691936

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.