Evidence map›Paper›PMID 33020052›Full record

Trial reportDiabetes care2020

Intratrial Exposure to Vitamin D and New-Onset Diabetes Among Adults With Prediabetes: A Secondary Analysis From the Vitamin D and Type 2 Diabetes (D2d) Study.

Bess Dawson-Hughes, Myrlene A Staten, William C Knowler, Jason Nelson, Ellen M Vickery, Erin S LeBlanc, Lisa M Neff, Jean Park, Anastassios G Pittas, D2d Research Group

Open access · bronzeAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Diabetes care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
111citing papers in PubMed, 10 pooled it
17.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

111 citing papers in PubMed, 10 syntheses or guidelines pooled it, 184 citations in OpenAlex.

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51 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Bess Dawson-HughesJean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA.
Myrlene A StatenNational Institute of Diabetes and Digestive and Kidney Diseases, Bethesda, MD.
William C KnowlerNational Institute of Diabetes and Digestive and Kidney Diseases, Phoenix, AZ.ORCID 0000-0002-7004-5197
Jason NelsonTufts Medical Center, Boston, MA.
Ellen M VickeryDivision of Endocrinology, Diabetes and Metabolism, Tufts Medical Center, Boston, MA.ORCID 0000-0002-0665-8749
Erin S LeBlancKaiser Permanente Center for Health Research Northwest, Portland, OR.ORCID 0000-0002-4067-3432
Lisa M NeffDivision of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL.
Jean ParkMedStar Health Research Institute, Hyattsville, MD.
Anastassios G PittasORCID 0000-0002-0124-7174
D2d Research Group
Tufts Medical Center · USNational Institute of Diabetes and Digestive and Kidney Diseases · USKaiser Permanente Center for Health Research · USMedStar Health · USNorthwestern University · USTufts University · US

Funding

Vitamin D and Type 2 Diabetes (D2d)U01DK098245 · NIDDK · TUFTS MEDICAL CENTER · PI PITTAS, ANASTASSIOS G · 2013 to 2020
$45.6M
NIDDK NIH HHS U01 DK098245
6 · The paper itself

Abstract

objectivePostrandomization biases may influence the estimate of efficacy of supplemental vitamin D in diabetes prevention trials. In the Vitamin D and Type 2 Diabetes (D2d) study, repeated measures of serum 25-hydroxyvitamin D [25(OH)D] level provided an opportunity to test whether intratrial vitamin D exposure affected diabetes risk and whether the effect was modified by trial assignment (vitamin D vs. placebo). RESEARCH DESIGN AND

methodsThe D2d study compared the effect of daily supplementation with 100 μg (4,000 units) of vitamin D

resultsThere was an interaction of trial assignment with intratrial 25(OH)D level in predicting diabetes risk (interaction

conclusionsDaily vitamin D supplementation to maintain a serum 25(OH)D level ≥100 nmol/L is a promising approach to reducing the risk of diabetes in adults with prediabetes.

Indexed as

Diabetes Mellitus, Type 2Prediabetic StateAdultHumansVitamin DVitaminsVitamin DVitamins

Identifiers

PMID33020052
PMCPMC7770274
OpenAlexW3090780683

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.