Evidence map›Paper›PMID 33020021›Full record

ReviewTrends in genetics : TIG2021

Epigenetic Regulation of Tick Biology and Vectorial Capacity.

Sandip De, Chrysoula Kitsou, Daniel E Sonenshine, Joao H F Pedra, Erol Fikrig, Judith A Kassis, Utpal Pal

Abstract readReview
In one paragraph

Review in Trends in genetics : TIG, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sandip DeDepartment of Veterinary Medicine, University of Maryland, College Park, MD, USA.
Chrysoula KitsouDepartment of Veterinary Medicine, University of Maryland, College Park, MD, USA.
Daniel E SonenshineLaboratory for Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, USA; Department of Biological Sciences, Old Dominion University, Norfolk, VA, USA.
Joao H F PedraDepartment of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, MD, USA.
Erol FikrigSection of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Judith A KassisEunice Kennedy Shriver National Institute of Child Health and Human Development National Institutes of Health, Bethesda, MD, USA.
Utpal PalDepartment of Veterinary Medicine, University of Maryland, College Park, MD, USA; Virginia-Maryland College of Veterinary Medicine, College Park, MD, USA. Electronic address: upal@umd.edu.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Control Of Gene Expression During DevelopmentZIAHD005003 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI KASSIS, JUDITH ANN · 2009 to 2023
$16.4M
Tick Resources CoreP01AI138949 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI Erol Fikrig · 2018 to 2026
$13.5M
Ubiquitylation and Rickettsial Colonization of a Tick VectorR01AI116523 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI PEDRA, JOAO · 2016 to 2025
$6.2M
BORRELIA GENE PRODUCTS CRITICAL FOR NATURAL INFECTION CYCLER01AI080615 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI PAL, UTPAL · 2009 to 2024
$5.2M
Tick Saliva and Pathogen TransmissionR01AI134696 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI Joao Pedra · 2018 to 2026
$5.1M
BBA57-Mediated Borrelial Persistence, Genesis of Inflammation and ImmunityR01AI116620 · NIAID · UNIV OF MARYLAND, COLLEGE PARK · PI PAL, UTPAL · 2015 to 2019
$1.9M
NCATS NIH HHS UL1 TR001863NIAID NIH HHS P01 AI138949NIAID NIH HHS R01 AI080615NIAID NIH HHS R01 AI116523NIAID NIH HHS R01 AI116620NIAID NIH HHS R01 AI134696
6 · The paper itself

Abstract

Ticks exist across diverse environments and transmit numerous pathogens. Due to their long and unique life cycles, these arthropods likely evolved robust epigenetic mechanisms that provide sustainable responses and buffers against extreme environmental conditions. Herein, we highlight how the study of the epigenetic basis of tick biology and vectorial capacity will enrich our knowledge of tick-borne infections.

Indexed as

Disease Transmission, InfectiousEpigenesis, GeneticHost-Pathogen InteractionsAnimalsArthropod VectorsHumansTick-Borne DiseasesTicksepigeneticsticks

Identifiers

PMID33020021
PMCPMC8008791

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.