Evidence map›Paper›PMID 33019903›Full record

ReviewWomen's health (London, England)

The role of aspirin in the prevention of ovarian, endometrial and cervical cancers.

Nalinie Joharatnam-Hogan, Fay H Cafferty, Archie Macnair, Alistair Ring, Ruth E Langley

Abstract readReview
In one paragraph

Review in Women's health (London, England). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Nalinie Joharatnam-HoganMRC Clinical Trials Unit, University College London, Institute of Clinical Trials & Methodology, London, UK.ORCID 0000-0001-8406-2732
Fay H CaffertyMRC Clinical Trials Unit, University College London, Institute of Clinical Trials & Methodology, London, UK.
Archie MacnairMRC Clinical Trials Unit, University College London, Institute of Clinical Trials & Methodology, London, UK.
Alistair RingRoyal Marsden Hospital, NHS Foundation Trust, London, UK.
Ruth E LangleyMRC Clinical Trials Unit, University College London, Institute of Clinical Trials & Methodology, London, UK.

Funding

Cancer Research UK 15015Cancer Research UK 26413Department of Health 12/01/38Medical Research Council MC_UU_12023/28
6 · The paper itself

Abstract

Drug repurposing is the application of an existing licenced drug for a new indication and potentially provides a faster and cheaper approach to developing new anti-cancer agents. Gynaecological cancers contribute significantly to the global cancer burden, highlighting the need for low cost, widely accessible therapies. A large body of evidence supports the role of aspirin as an anti-cancer agent, and a number of randomized trials are currently underway aiming to assess the potential benefit of aspirin in the treatment of cancer. This review summarizes the evidence underpinning aspirin use for the prevention of the development and recurrence of gynaecological cancers (ovarian, endometrial and cervical) and potential mechanisms of action.

Indexed as

Anti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsAspirinEndometrial NeoplasmsFemaleHumansNeoplasm Recurrence, LocalOvarian NeoplasmsUterine Cervical NeoplasmsAnti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsAspirinaspirincervical cancerendometrial cancerovarian cancer

Identifiers

PMID33019903
PMCPMC7543116

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.