Evidence map›Paper›PMID 33019895›Full record

ArticleStroke2020

Chronic Kidney Disease as Risk Factor for Enlarged Perivascular Spaces in Patients With Stroke and Relation to Racial Group.

Ashley A Penton, Helena Lau, Viken L Babikian, Julie Shulman, Anna Cervantes-Arslanian, Suhas Gangadhara, David Greer, Hugo J Aparicio, Jose R Romero

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stroke, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.7field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  3. Impaired kidney function, cerebral small vessel disease and cognitive disorders: the Framingham Heart Study.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 3 countries.

Ashley A PentonDepartment of Neurology, Boston University School of Medicine, MA (A.A.P., H.L., V.L.B., J.S., A.C.-A., S.G., D.G., H.J.A., J.R.R.).
Helena LauDepartment of Neurology, Boston University School of Medicine, MA (A.A.P., H.L., V.L.B., J.S., A.C.-A., S.G., D.G., H.J.A., J.R.R.).
Viken L BabikianDepartment of Neurology, Boston University School of Medicine, MA (A.A.P., H.L., V.L.B., J.S., A.C.-A., S.G., D.G., H.J.A., J.R.R.).
Julie ShulmanDepartment of Neurology, Boston University School of Medicine, MA (A.A.P., H.L., V.L.B., J.S., A.C.-A., S.G., D.G., H.J.A., J.R.R.).
Anna Cervantes-ArslanianDepartment of Neurology, Boston University School of Medicine, MA (A.A.P., H.L., V.L.B., J.S., A.C.-A., S.G., D.G., H.J.A., J.R.R.).
Suhas GangadharaDepartment of Neurology, Boston University School of Medicine, MA (A.A.P., H.L., V.L.B., J.S., A.C.-A., S.G., D.G., H.J.A., J.R.R.).
David GreerDepartment of Neurology, Boston University School of Medicine, MA (A.A.P., H.L., V.L.B., J.S., A.C.-A., S.G., D.G., H.J.A., J.R.R.).
Hugo J AparicioDepartment of Neurology, Boston University School of Medicine, MA (A.A.P., H.L., V.L.B., J.S., A.C.-A., S.G., D.G., H.J.A., J.R.R.).
Jose R RomeroDepartment of Neurology, Boston University School of Medicine, MA (A.A.P., H.L., V.L.B., J.S., A.C.-A., S.G., D.G., H.J.A., J.R.R.).
Anna Needs Neuroblastoma Answers · USMACOM (United States) · USVA Boston Healthcare System · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
PRECURSORS OF STROKE INCIDENCE AND PROGNOSISR01NS017950 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Hugo Javier Aparicio, Jose Rafael Romero · 1985 to 2026
$22.9M
EPIDEMIOLOGY OF DEMENTIA IN THE FRAMINGHAM STUDYR01AG008122 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AU, RHODA, SESHADRI, SUDHA · 1989 to 2015
$14.4M
Collaborative GWAS of Dementia, AD and related MRI and Cognitive EndophenotypesR01AG033193 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI SESHADRI, SUDHA · 2009 to 2016
$4.4M
Enlarged Perivascular Spaces as Markers of Vascular and Alzheimer pathology: predictors, pathophysiology and clinical consequencesR01AG059725 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROMERO, JOSE RAFAEL · 2019 to 2023
$3.1M
Risk Factors, Genetics and Cognition in Cerebral Microbleeds: Framingham StudyK23AG038444 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROMERO, JOSE RAFAEL · 2011 to 2015
$644k
Cerebral Microbleeds in Young Adults: risk factors, biomarkers and geneticsR03AG048180 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ROMERO, JOSE RAFAEL · 2015 to 2016
$164k
THE FRAMINGHAM HEART STUDY-N01HC25195-268025195-268025195N01HC025195 · HC · TRUSTEES OF BOSTON UNIVERSITY · PI WOLF, PHILIP A · 2002 to 2006
–
NCATS NIH HHS UL1 TR001863NHLBI NIH HHS HHSN268201500001CNHLBI NIH HHS HHSN268201500001INHLBI NIH HHS N01 HC025195NIA NIH HHS K23 AG038444NIA NIH HHS R01 AG008122NIA NIH HHS R01 AG033193NIA NIH HHS R01 AG059725NIA NIH HHS R03 AG048180NINDS NIH HHS R01 NS017950
6 · The paper itself

Abstract

background and purposeEnlarged perivascular spaces (EPVS) are considered subclinical markers of small vessel disease, associated with increased risk of stroke and dementia. Increasing evidence links chronic kidney disease (CKD) to small vessel disease. We explored the relationship between CKD and EPVS burden and the influence of racial group in this relation.

methodsConsecutive patients with stroke who underwent brain magnetic resonance imaging were included (n=894). Racial group was categorized as White, Black, or other (other racial groups). CKD was defined by glomerular filtration rate <60 mL/minute per 1.73 m

resultsIn multivariable-adjusted analysis, the association of CKD with severe EPVS varied across racial groups. Comparing patients with and without CKD within racial groups, we found that Whites with CKD had higher odds of severe centrum semiovale EPVS (odds ratio [OR], 2.41 [95% CI, 0.98-5.88]). Among patients with CKD, Black patients had higher odds of severe EPVS in the basal ganglia and centrum semiovale compared with Whites (OR, 1.93 [95% CI, 1.18-3.16] and OR, 1.90 [95% CI, 1.16-3.11], respectively) and other racial groups (OR, 2.03 [95% CI, 1.23-3.36] and OR, 2.02 [95% CI, 1.22-3.34], respectively).

conclusionsCKD was more prevalent in our sample of patients with stroke with severe EPVS in the centrum semiovale. The relation differed when stratified by racial group and brain topography. Further studies are needed to confirm that CKD may relate differently to subclinical measures of small vessel disease according to race.

Indexed as

AgedAged, 80 and overBasal GangliaBlack or African AmericanCerebral Small Vessel DiseasesFemaleGlymphatic SystemHemorrhagic StrokeHumansIschemic Attack, TransientIschemic StrokeLymphatic DiseasesMaleMiddle AgedOdds RatioRenal Insufficiency, Chronicbasal gangliabrain diseasesdementiaglomerular filtration ratekidney diseasesmagnetic resonance imaging

Identifiers

PMID33019895
PMCPMC7606816
OpenAlexW3091564973

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.