Evidence map›Paper›PMID 33019787›Full record

ArticleAntibiotics (Basel, Switzerland)2020

Mutually Isomeric 2- and 4-(3-nitro-1,2,4-triazol-1-yl)pyrimidines Inspired by an Antimycobacterial Screening Hit: Synthesis and Biological Activity against the ESKAPE Panel of Pathogens.

Sergey Chuprun, Dmitry Dar'in, Elizaveta Rogacheva, Liudmila Kraeva, Oleg Levin, Olga Manicheva, Marine Dogonadze, Tatiana Vinogradova, Olga Bakulina, Mikhail Krasavin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antibiotics (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Sergey ChuprunInstitute of Chemistry, Saint Petersburg State University, 199034 Saint Petersburg, Russia.
Dmitry Dar'inInstitute of Chemistry, Saint Petersburg State University, 199034 Saint Petersburg, Russia.ORCID 0000-0002-0413-7413
Elizaveta RogachevaPasteur Institute of Epidemiology and Microbiology, 14 Mira Street, 197101 Saint Petersburg, Russia.
Liudmila KraevaPasteur Institute of Epidemiology and Microbiology, 14 Mira Street, 197101 Saint Petersburg, Russia.
Oleg LevinInstitute of Chemistry, Saint Petersburg State University, 199034 Saint Petersburg, Russia.ORCID 0000-0002-4538-316X
Olga ManichevaSaint Petersburg Research Institute of Phthisiopulmonology, 2-4 Ligovsky Prospekt, 191036 Saint Petersburg, Russia.
Marine DogonadzeSaint Petersburg Research Institute of Phthisiopulmonology, 2-4 Ligovsky Prospekt, 191036 Saint Petersburg, Russia.
Tatiana VinogradovaSaint Petersburg Research Institute of Phthisiopulmonology, 2-4 Ligovsky Prospekt, 191036 Saint Petersburg, Russia.
Olga BakulinaInstitute of Chemistry, Saint Petersburg State University, 199034 Saint Petersburg, Russia.
Mikhail KrasavinInstitute of Chemistry, Saint Petersburg State University, 199034 Saint Petersburg, Russia.ORCID 0000-0002-0200-4772
St Petersburg University · RUSaint-Petersburg Research Institute of Phthisiopulmonology · RUSaint Petersburg Pasteur Institute · RUImmanuel Kant Baltic Federal University · RU

Funding

Ministry of Science and Higher Education of the Russian Federation 14.W03.031.0025
6 · The paper itself

Abstract

Starting from the structure of antimycobacterial screening hit OTB-021 which was devoid of activity against ESKAPE pathogens, we designed, synthesized and tested two mutually isomeric series of novel simplified analogs, 2- and 4-(3-nitro-1,2,4-triazol-1-yl)pyrimidines, bearing various amino side chains. These compounds demonstrated a reverse bioactivity profile being inactive against

Indexed as

3-nitro-1,2,4-triazoleantimycobacterial activitybioreducible prodrugscyclic voltammetryESKAPE pathogensnitroazolesnucleophilic aromatic substitutionreversible single-electron reduction

Identifiers

PMID33019787
PMCPMC7601023
OpenAlexW3089995944

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.