ArticleInternational journal of molecular sciences2020
Excess Protein O-GlcNAcylation Links Metabolic Derangements to Right Ventricular Dysfunction in Pulmonary Arterial Hypertension.
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Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
7.0field-weighted citation impact, top 2% of its field
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Who cites it
21 citing papers in PubMed, 69 citations in OpenAlex.
- O-GlcNAcylation as a Metabolic Integrator in Cardiovascular Physiology and Disease.International journal of molecular sciences · 2026Review
- CHCHD3(MIC19): mitochondrial cristae structure regulation and disease associations.Frontiers in molecular biosciences · 2026Review
- Glutamine: fructose-6-phosphate amidotransferase (GFAT) in the pathology of diseases: a review.Cell death discovery · 2025Review
- Chronic hyperglycemia and cardiovascular dysfunction: an in-depth exploration of metabolic and cellular pathways in type 2 diabetes mellitus.Cardiovascular diabetology. Endocrinology reports · 2025Review
- Reprogrammed glucose metabolism in vascular smooth muscle cells and its implications for vascular diseases.Pharmacological research · 2025Review
- GP130 Antagonism Enhances Porcine RV Function.Circulation research · 2025Article
- Glycoprotein 130 Antagonism Counteracts Metabolic and Inflammatory Alterations to Enhance Right Ventricle Function in Pulmonary Artery Banded Pigs.bioRxiv : the preprint server for biology · 2025Article
- Improving metabolic support during normothermicFrontiers in cardiovascular medicine · 2025Review
- Pulmonary hypertension.Nature reviews. Disease primers · 2024Review
- O-GlcNAc transferase regulates collagen deposition and fibrosis resolution in idiopathic pulmonary fibrosis.Frontiers in immunology · 2024Article
- Acquired disorders of mitochondrial metabolism and dynamics in pulmonary arterial hypertension.Frontiers in cell and developmental biology · 2023Review
- O-GlcNAcylation is crucial for sympathetic neuron development, maintenance, functionality and contributes to peripheral neuropathy.Frontiers in neuroscience · 2023Article
- Nutrient-sensitive protein O-GlcNAcylation shapes daily biological rhythms.Open biology · 2022Review
- The Glycobiology of Pulmonary Arterial Hypertension.Metabolites · 2022Review
- Metabolism, Mitochondrial Dysfunction, and Redox Homeostasis in Pulmonary Hypertension.Antioxidants (Basel, Switzerland) · 2022Review
- Deduction and exploration of the evolution and function of vertebrate GFPT family.Genes & genomics · 2022Article
- The dual role of the hexosamine biosynthetic pathway in cardiac physiology and pathophysiology.Frontiers in endocrinology · 2022Review
- An integrated proteomic and transcriptomic signature of the failing right ventricle in monocrotaline induced pulmonary arterial hypertension in male rats.Frontiers in physiology · 2022Article
- Inflammatory Glycoprotein 130 Signaling Links Changes in Microtubules and Junctophilin-2 to Altered Mitochondrial Metabolism and Right Ventricular Contractility.Circulation. Heart failure · 2022Article
- Oxygen sensing, mitochondrial biology and experimental therapeutics for pulmonary hypertension and cancer.Free radical biology & medicine · 2021Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Sasha Z PriscoCardiovascular Division, Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-9059-0635
Lauren RoseCardiovascular Division, Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Francois PotusDepartment of Medicine, Queen's University, Kingston, ON K7L3N6, Canada.ORCID 0000-0003-1745-6445
Lian TianDepartment of Medicine, Queen's University, Kingston, ON K7L3N6, Canada.
Danchen WuDepartment of Medicine, Queen's University, Kingston, ON K7L3N6, Canada.
Lynn HartweckCardiovascular Division, Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Ruaa Al-QazaziDepartment of Medicine, Queen's University, Kingston, ON K7L3N6, Canada.
Monica Neuber-HessDepartment of Medicine, Queen's University, Kingston, ON K7L3N6, Canada.
Megan EklundCardiovascular Division, Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Steven HsuDivision of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
Thenappan ThenappanCardiovascular Division, Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Stephen L ArcherDepartment of Medicine, Queen's University, Kingston, ON K7L3N6, Canada.ORCID 0000-0003-1106-3202
Kurt W PrinsCardiovascular Division, Lillehei Heart Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Queen's University · CAUniversity of Minnesota · USJohns Hopkins University · US
Funding
Training Program in Cardiac InnovationT32HL144472 · NHLBI · UNIVERSITY OF MINNESOTA · PI Peter A Crawford, SAMUEL C DUDLEY · 2019 to 2026
$2.6MMechanisms and treatment of right ventricular sarcomere dysfunction in scleroderma-associated pulmonary arterial hypertensionK23HL146889 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI HSU, STEVEN · 2019 to 2023
$886kMechanisms of Junctophilin-2 Misregulation that contribute to right ventricular dysfunction in pulmonary arterial hypertensionK08HL140100 · NHLBI · UNIVERSITY OF MINNESOTA · PI PRINS, KURT W · 2018 to 2022
$785kNHLBI NIH HHS HL140100NHLBI NIH HHS K08 HL140100NHLBI NIH HHS K23 HL146889NHLBI NIH HHS T32 HL144472
Abstract
The hexosamine biosynthetic pathway (HBP) converts glucose to uridine-diphosphate-
Indexed as
Protein Processing, Post-TranslationalAcylationAdultAgedAMP-Activated Protein KinasesAnimalsCell LineCohort StudiesColchicineDiabetes MellitusDisease Models, AnimalEchocardiographyGene Expression RegulationGlutamine-Fructose-6-Phosphate Transaminase (Isomerizing)HexosaminesHumansAMP-Activated Protein KinasesColchicineGlutamine-Fructose-6-Phosphate Transaminase (Isomerizing)HexosaminesMonocrotalinemetabolismmitochondriapost-translational modificationpulmonary hypertensionright ventricle
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.