SARs for the Antiparasitic Plant Metabolite Pulchrol. Part 2: B- and C-Ring Substituents.

Paola Terrazas, Sophie Manner, Olov Sterner, Marcelo Dávila, Alberto Giménez, Efrain Salamanca

Abstract read

In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

SARs for the Antiparasitic Plant Metabolite Pulchrol. 3. Combinations of New Substituents in A/B-Rings and A/C-Rings.Molecules (Basel, Switzerland) · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Paola TerrazasDepartment of Chemistry, Centre for Analysis and Synthesis, Lund University, 22100 Lund, Sweden.ORCID 0000-0003-2282-8493

Sophie MannerDepartment of Chemistry, Centre for Analysis and Synthesis, Lund University, 22100 Lund, Sweden.ORCID 0000-0002-3492-5066

Olov SternerDepartment of Chemistry, Centre for Analysis and Synthesis, Lund University, 22100 Lund, Sweden.

Marcelo DávilaCentre of Agroindustrial Technology, San Simón University, Cochabamba 3299, Bolivia.

Alberto GiménezInstitute for Pharmacological and Biochemical Sciences, San Andrés University, La Paz 3299, Bolivia.

Efrain SalamancaInstitute for Pharmacological and Biochemical Sciences, San Andrés University, La Paz 3299, Bolivia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neglected tropical diseases affect most of the underprivileged populations in tropical countries. Among these are chagas and leishmaniasis, present mainly in South and Central America, Africa and East Asia. Current treatments are long and have severe adverse effects, therefore there is a strong need to develop alternatives. In this study, we base our research on the plant metabolite pulchrol, a natural benzochromene which has been shown to possess antiparasitic activity against

Indexed as

MetabolomeAntiparasitic AgentsCarbon-13 Magnetic Resonance SpectroscopyCell DeathDronabinolInhibitory Concentration 50LeishmaniaPlantsStructure-Activity RelationshipTrypanosoma cruziAntiparasitic AgentsDronabinolbenzo[c]chromenesLeishmania amazonensisLeishmania braziliensispulchrolStructure-Activity Relationships (SARs)Trypanosoma cruzi

Identifiers

PMID33019678

DOI10.3390/molecules25194510

PMCPMC7582507

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.