Evidence map›Paper›PMID 33019655›Full record

ArticleFoods (Basel, Switzerland)2020

By-Products from Winemaking and Olive Mill Value Chains for the Enrichment of Refined Olive Oil: Technological Challenges and Nutraceutical Features.

Monica Macaluso, Alessandro Bianchi, Chiara Sanmartin, Isabella Taglieri, Francesca Venturi, Lara Testai, Lorenzo Flori, Vincenzo Calderone, Marinella De Leo, Alessandra Braca and 4 more

Abstract read
In one paragraph

Article in Foods (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Nutrients · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Effect of Fertilization Regime of Common Wheat (Foods (Basel, Switzerland) · 2023
    Article
  7. Valorization of an Old Variety ofFoods (Basel, Switzerland) · 2023
    Article
  8. Jellyfish Polysaccharides for Wound Healing Applications.International journal of molecular sciences · 2022
    Article
  9. Article
  10. Article
  11. Bread Fortified with Cooked Purple Potato Flour andFoods (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Monica MacalusoDepartment of Agriculture, Food and Environment (DAFE), University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.
Alessandro BianchiDepartment of Agriculture, Food and Environment (DAFE), University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.
Chiara SanmartinDepartment of Agriculture, Food and Environment (DAFE), University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.ORCID 0000-0002-7559-1955
Isabella TaglieriDepartment of Agriculture, Food and Environment (DAFE), University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.ORCID 0000-0001-6000-9371
Francesca VenturiDepartment of Agriculture, Food and Environment (DAFE), University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.ORCID 0000-0002-7844-3253
Lara TestaiInterdepartmental Research Center "Nutraceuticals and Food for Health", University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.ORCID 0000-0003-2431-6248
Lorenzo FloriDepartment of Life Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.
Vincenzo CalderoneInterdepartmental Research Center "Nutraceuticals and Food for Health", University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.
Marinella De LeoInterdepartmental Research Center "Nutraceuticals and Food for Health", University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.ORCID 0000-0002-5544-8457
Alessandra BracaInterdepartmental Research Center "Nutraceuticals and Food for Health", University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.ORCID 0000-0002-9838-0448
Valerio CicconeDepartment of Pharmacy, University of Pisa, Via Bonanno Pisano 6, 56126 Pisa, Italy.ORCID 0000-0002-5374-9694
Sandra DonniniDepartment of Life Sciences, University of Siena, Via Aldo Moro 2, 53100 Siena, Italy.ORCID 0000-0001-6617-1644
Luca GuidiSALOV S.p.A., Via di Montramito, 1600, 55054 Massarosa, Italy.
Angela ZinnaiDepartment of Agriculture, Food and Environment (DAFE), University of Pisa, Via del Borghetto 80, 56124 Pisa, Italy.

Funding

Regione Toscana D56G18000160009
6 · The paper itself

Abstract

A growing body of literature is available about the valorization of food by-products to produce functional foods that combine the basic nutritional impact with the improvement of the health status of consumers. In this context, this study had two main objectives: (i) An innovative multistep extraction process for the production of a refined olive oil enriched with phenolic compounds (PE-ROO) extracted from olive pomace, olive leaves, or grape marc was presented and discussed. (ii) The most promising PE-ROOs were selected and utilized in in vitro and in vivo trials in order to determine their effectiveness in the management of high fat diet-induced-metabolic syndrome and oxidative stress in rats. The best results were obtained when olive leaves were used as source of phenols, regardless of the chemical composition of the solvent utilized for the extraction. Furthermore, while ethanol/hexane mixture was confirmed as a good solvent for the extraction of phenols compounds soluble in oil, the mix ROO/ethanol also showed a good extracting power from olive leaves. Besides, the ROO enriched with phenols extracted from olive leaves revealed an interesting beneficial effect to counteract high fat diet-induced-metabolic disorder and oxidative stress in rats, closely followed by ROO enriched by utilizing grape marc.

Indexed as

cancer diseasescardiovascular diseasesgrape marcin vitro modelin vivo modelmetabolic syndromeolive leavesolive pomacephenol-enriched olive oilphenols

Identifiers

PMID33019655
PMCPMC7601883

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.