Evidence map›Paper›PMID 33019603›Full record

ArticleInternational journal of molecular sciences2020

RAGE Mediates Cholesterol Efflux Impairment in Macrophages Caused by Human Advanced Glycated Albumin.

Adriana Machado-Lima, Raquel López-Díez, Rodrigo Tallada Iborra, Raphael de Souza Pinto, Gurdip Daffu, Xiaoping Shen, Edna Regina Nakandakare, Ubiratan Fabres Machado, Maria Lucia Cardillo Corrêa-Giannella, Ann Marie Schmidt and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Obesity-Related Glomerulosclerosis-How Adiposity Damages the Kidneys.International journal of molecular sciences · 2025
    Review
  2. Article
  3. S100A8/A9-activated IFNγCellular and molecular life sciences : CMLS · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 2 countries.

Adriana Machado-LimaLaboratório de Lípides (LIM 10), Hospital das Clínicas (HCFMUSP), Faculdade de Medicina da Universidade de São Paulo, São Paulo CEP 01246-000, Brazil.ORCID 0000-0002-5741-3418
Raquel López-DíezDepartment of Medicine, Diabetes Research Program, New York University Langone Health, New York, NY 10016, USA.ORCID 0000-0003-4468-4654
Rodrigo Tallada IborraLaboratório de Lípides (LIM 10), Hospital das Clínicas (HCFMUSP), Faculdade de Medicina da Universidade de São Paulo, São Paulo CEP 01246-000, Brazil.ORCID 0000-0002-3772-4200
Raphael de Souza PintoLaboratório de Lípides (LIM 10), Hospital das Clínicas (HCFMUSP), Faculdade de Medicina da Universidade de São Paulo, São Paulo CEP 01246-000, Brazil.ORCID 0000-0002-2633-651X
Gurdip DaffuDepartment of Medicine, Diabetes Research Program, New York University Langone Health, New York, NY 10016, USA.
Xiaoping ShenDepartment of Medicine, Diabetes Research Program, New York University Langone Health, New York, NY 10016, USA.
Edna Regina NakandakareLaboratório de Lípides (LIM 10), Hospital das Clínicas (HCFMUSP), Faculdade de Medicina da Universidade de São Paulo, São Paulo CEP 01246-000, Brazil.
Ubiratan Fabres MachadoLaboratório de Metabolismo e Endocrinologia, Instituto de Ciências Biomédicas da Universidade de São Paulo, São Paulo CEP 05508-000, Brazil.ORCID 0000-0002-8237-2435
Maria Lucia Cardillo Corrêa-GiannellaLaboratório de Carboidratos e Radioimunoensaio (LIM 18), Hospital das Clínicas (HCFMUSP), Faculdade de Medicina da Universidade de São Paulo, São Paulo CEP 01246-000, Brazil.ORCID 0000-0003-3655-4446
Ann Marie SchmidtDepartment of Medicine, Diabetes Research Program, New York University Langone Health, New York, NY 10016, USA.
Marisa PassarelliLaboratório de Lípides (LIM 10), Hospital das Clínicas (HCFMUSP), Faculdade de Medicina da Universidade de São Paulo, São Paulo CEP 01246-000, Brazil.
NYU Langone Health · USHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRUniversidade Nove de Julho · BRCentro Universitário Cesmac · BRUniversidade de São Paulo · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 13/06800-9Fundação de Amparo à Pesquisa do Estado de São Paulo 14/05951-6
6 · The paper itself

Abstract

We addressed the involvement of the receptor for advanced glycation end products (RAGE) in the impairment of the cellular cholesterol efflux elicited by glycated albumin. Albumin was isolated from type 1 (DM1) and type 2 (DM2) diabetes mellitus (HbA1c > 9%) and non-DM subjects (C). Moreover, albumin was glycated in vitro (AGE-albumin). Macrophages from

Indexed as

AdultAnimalsCase-Control StudiesCell LineCholesterol, HDLCholesterol, LDLDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2FemaleFibroblastsGene Expression RegulationGlycated HemoglobinGlycation End Products, AdvancedHumansJanus Kinase 2MacrophagesAGER protein, humanAger protein, mouseCholesterol, HDLCholesterol, LDLGlycated HemoglobinGlycation End Products, Advancedhemoglobin A1c protein, humanJAK2 protein, humanJanus Kinase 2NADPH Oxidase 4NF-kappa B p50 SubunitNFKB1 protein, humanNOX4 protein, humanReceptor for Advanced Glycation End ProductsRNA, Small InterferingSerum Albumin, HumanTriglyceridesadvanced glycation end productsatherosclerosischolesteroldiabetes mellitusRAGE

Identifiers

PMID33019603
PMCPMC7582519
OpenAlexW3090779333

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.