Evidence map›Paper›PMID 33019428›Full record

Observational studyMedicine2020

Delivery mode-associated gut microbiota in the first 3 months of life in a country with high obesity rates: A descriptive study.

Chiharu Murata, Pedro Gutiérrez-Castrellón, Fernando Pérez-Villatoro, Itzhel García-Torres, Sergio Enríquez-Flores, Ignacio de la Mora-de la Mora, Cynthia Fernández-Lainez, Julieta Werner, Gabriel López-Velázquez

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

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  7. Prevention of Metabolic Syndrome by Phytochemicals and Vitamin D.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Chiharu MurataResearch Methodology Department. National Institute of Pediatrics, Mexico.
Pedro Gutiérrez-CastrellónGeneral Hospital Dr. Manuel Gea González.
Fernando Pérez-VillatoroWinter Genomics.
Itzhel García-TorresGroup of Research on Biomolecules and Infant Health, IEM&S Lab. INP, México.
Sergio Enríquez-FloresGroup of Research on Biomolecules and Infant Health, IEM&S Lab. INP, México.
Ignacio de la Mora-de la MoraGroup of Research on Biomolecules and Infant Health, IEM&S Lab. INP, México.
Cynthia Fernández-LainezLaboratory of Inborn Errors of Metabolism and Screening, INP, and Postgraduate in Biological Sciences, UNAM, México. Actual Address: Immunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
Julieta WernerIndigenous Services Canada, Thunder Bay, Ontario, Canada.
Gabriel López-VelázquezGroup of Research on Biomolecules and Infant Health, IEM&S Lab. INP, México.ORCID 0000-0003-0470-1069
Hospital General Dr. Manuel Gea Gonzalez · MXUniversity of Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Delivery methods during childbirth and their related gut microbiota profiles have important impacts on health later in life, they can contribute to the development of diseases such as obesity, whose highest prevalence rate is found among the Mexican child population. Coincidentally, Mexico has one of the highest global average annual rate increase in cesarean births (C-section). Since Mexico leads the world in childhood obesity, studying the relationship between childbirth delivery methods and gut microbiota profiles in this vulnerable population may be used to identify early risk factors for obesity in other developed and developing countries. The objective of this study is to determine the association between child delivery method and gut microbiota profiles in healthy Mexican newborns.Fecal samples of 57 term infants who participated in a randomized clinical trial in 2013 to study the safety of Agave fructans in newborns, were used in this study. DNA samples were extracted and used to characterize the microbiota composition using high-throughput 16S rRNA gene sequencing. The samples were further divided based on childbirth delivery method, as well as early diet. Gut microbiota profiles were determined and analyzed using cluster analysis followed by multiple correspondence analysis.An unusual high abundance of Proteobacteria was found in the gut microbiota of all Mexican infants studied, regardless of delivery method. Feces from infants born by C-section had low levels of Bacteroidetes, high levels of Firmicutes, especially Clostridium and Enterococcus, and a strikingly high ratio of Firmicutes/Bacteroidetes (F:B). Profiles enriched in Bacteroidetes and low F:B ratios, were strongly associated with vaginal delivery.The profile of gut microbiota associated with feces from Mexican infants born by C-section, may be added to the list of boosting factors for the worrying obesity epidemic in Mexico.

Indexed as

Gastrointestinal MicrobiomeCesarean SectionFecesFemaleHumansInfantInfant, NewbornMaleMexicoObesityRisk Factors

Identifiers

PMID33019428
PMCPMC7535699
OpenAlexW3090409532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.