Evidence map›Paper›PMID 33018417›Full record

ArticleAnnual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference2020

Study of the Relationship Between Ultrasound Strain Indices and Cognitive Decline for Vulnerable Carotid Plaque.

Nirvedh H Meshram, Daren Jackson, Carol C Mitchell, Stephanie M Wilbrand, Robert J Dempsey, Bruce P Hermann, Tomy Varghese

Abstract read
In one paragraph

Article in Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Nirvedh H Meshram
Daren Jackson
Carol C Mitchell
Stephanie M Wilbrand
Robert J Dempsey
Bruce P Hermann
Tomy Varghese

Funding

Early Detection of Vascular Dysfunction Using Biomarkers from Lagrangian Carotid Strain ImagingR01HL147866 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI VARGHESE, TOMY · 2020 to 2023
$2.9M
Real-time Ultrasonic Monitoring of Tumor AblationR01CA112192 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI VARGHESE, TOMY · 2007 to 2017
$2.6M
Structural Stability of Carotid Plaque and SymptomatologyR01NS064034 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI DEMPSEY, ROBERT J · 2010 to 2014
$1.5M
NCI NIH HHS R01 CA112192NHLBI NIH HHS R01 HL147866NINDS NIH HHS R01 NS064034
6 · The paper itself

Abstract

A relationship between ultrasound strain indices in carotid plaque to cognitive domains of executive and language function are studied in 42 symptomatic and 34 asymptomatic patients. The mean and standard deviation of the percentage stenosis were 72.10 ± 15.19 and 77.41 ± 11.20 for symptomatic and asymptomatic patients respectively. Pearson's correlation between axial, lateral and shear strain indices versus executive and language composite scores was performed.. A significant inverse correlation for both executive and language function for symptomatic patients to strain indices was found. On the other hand, for asymptomatic patients only executive function was inversely correlated with the corresponding strain indices. Our hypothesis that microemboli from vulnerable plaque and possible 'silent strokes' may be responsible for decline in executive function for both symptomatic and asymptomatic patients'. Strokes and transient ischemic attacks may be responsible for further cognitive decline in language function for symptomatic patients.

Indexed as

Carotid StenosisCognitive DysfunctionPlaque, AtheroscleroticHumansPlaque, AmyloidUltrasonography

Identifiers

PMID33018417
PMCPMC8063208

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.