Evidence map›Paper›PMID 33017670›Full record

ArticleExperimental gerontology2020

Myogenic marker expression as a function of age and exercise-based therapy in the tongue.

Heidi Kletzien, Cynthia A Kelm-Nelson, Sabrina Wang, Masatoshi Suzuki, Nadine P Connor

Open access · greenAbstract read
In one paragraph

Article in Experimental gerontology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Tongue blade neuromuscular junction defects in old F344 rats.Respiratory physiology & neurobiology · 2026
    Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Heidi KletzienDepartment of Biomedical Engineering, University of Wisconsin-Madison, United States of America; Department of Surgery, University of Wisconsin School of Medicine and Public Health, United States of America; Department of Stem Cell and Regenerative Biology, Harvard University, United States of America. Electronic address: hkletzien@fas.harvard.edu.
Cynthia A Kelm-NelsonDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, United States of America.
Sabrina WangDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, United States of America.
Masatoshi SuzukiDepartment of Biomedical Engineering, University of Wisconsin-Madison, United States of America; Department of Comparative Biosciences, University of Wisconsin-Madison, United States of America.
Nadine P ConnorDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, United States of America; Department of Communication Sciences and Disorders, University of Wisconsin-Madison, United States of America.
University of Wisconsin–Madison · USHarvard University · US

Funding

University of Wisconsin Voice Research Training Program (T32)T32DC009401 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI Susan Lynn Thibeault · 2009 to 2026
$6.3M
Lingual and Laryngeal Muscle PlasticityR01DC008149 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI CONNOR, NADINE P · 2007 to 2017
$4.5M
Exercise as a Treatment for Tongue Weakness in Aged RatsR01DC005935 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI CONNOR, NADINE P · 2003 to 2014
$3.3M
Pathways, mechanisms, and treatments of vocal communication deficits in a Parkinson rat modelR01NS117469 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI Cynthia A Kelm-Nelson · 2020 to 2026
$3.0M
Influence of neuromuscular pathology on parkinsonian communication deficitsR01DC014358 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI CIUCCI, MICHELLE RENEE, CONNOR, NADINE P · 2015 to 2019
$2.7M
Bioenergetic Mechanisms of Tongue Muscle FatigueR01DC018071 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI CONNOR, NADINE P · 2019 to 2023
$2.5M
Treatment of Functional Deficits IN tongue muscles induced by radiation and chemoradiation treatmentR37CA225608 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI RUSSELL, JOHN A · 2018 to 2024
$2.4M
Stem cell-based tissue engineering for myotendinous junction modeling and repairR01AR077191 · NIAMS · UNIVERSITY OF WISCONSIN-MADISON · PI SUZUKI, MASATOSHI · 2020 to 2024
$1.7M
Muscle stem cells: New ALS growth factor therapy and disease modelR01NS091540 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI SUZUKI, MASATOSHI · 2015 to 2019
$1.7M
Communication dysfunction in Parkinson disease: Integrated genetic and protein expression analysis of neural pathways to identify treatment targetsR21DC016135 · NIDCD · UNIVERSITY OF WISCONSIN-MADISON · PI KELM-NELSON, CYNTHIA A · 2018 to 2020
$459k
Mechanisms of lingual muscle regenerative capacity as a function of age and exercise-based therapyF31AG054315 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI KLETZIEN, HEIDI · 2017 to 2018
$81k
NCI NIH HHS R37 CA225608NIAMS NIH HHS R01 AR077191NIA NIH HHS F31 AG054315NIDCD NIH HHS R01 DC005935NIDCD NIH HHS R01 DC008149NIDCD NIH HHS R01 DC014358NIDCD NIH HHS R01 DC018071NIDCD NIH HHS R21 DC016135NIDCD NIH HHS T32 DC009401NINDS NIH HHS R01 NS091540NINDS NIH HHS R01 NS117469
6 · The paper itself

Abstract

Degeneration of tongue muscles with aging may contribute to swallowing deficits observed in elderly people. However, the capacity for tongue muscle stem cells (SCs) to regenerate and repair the aged tongue and improve tongue strength following tongue exercise (a current clinical treatment) has never been examined. We found that the expression of regenerative, myogenic markers were impaired with age and may be related to increased expression of senescent marker p16

Indexed as

DeglutitionTongueAgedAgingAnimalsExercise TherapyHumansMuscle, SkeletalRatsAgingDysphagiaExerciseMuscle stem cellsSwallowing

Identifiers

PMID33017670
PMCPMC7748063
OpenAlexW3090822853

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.