Evidence map›Paper›PMID 33017631›Full record

ArticleFree radical biology & medicine2020

Mitochondrial dysfunction promotes aquaporin expression that controls hydrogen peroxide permeability and ferroptosis.

Yuko Takashi, Kazuo Tomita, Yoshikazu Kuwahara, Mehryar Habibi Roudkenar, Amaneh Mohammadi Roushandeh, Kento Igarashi, Taisuke Nagasawa, Yoshihiro Nishitani, Tomoaki Sato

Abstract read
In one paragraph

Article in Free radical biology & medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.

0numbers the graph read from it
0cells of the map it votes in
55citing papers in PubMed
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

55 citing papers in PubMed, 104 citations in OpenAlex.

  1. Review
  2. Review
  3. CypD Dependent mPTP Opening Is Crucial for Oxidized Mitochondrial DNA Release in Ferroptosis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Journal of dental sciences · 2026
    Article
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Mitochondrial Regulation of Ferroptosis in Cancer Cells.International journal of biological sciences · 2025
    Review
  14. Review
  15. Article
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  17. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Yuko TakashiDepartment of Applied Pharmacology, Kagoshima, Japan; Restorative Dentistry and Endodontology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Kazuo TomitaDepartment of Applied Pharmacology, Kagoshima, Japan.
Yoshikazu KuwaharaDepartment of Applied Pharmacology, Kagoshima, Japan; Division of Radiation Biology and Medicine, Faculty of Medicine, Tohoku Medical and Pharmaceutical University, Sendai, Japan.
Mehryar Habibi RoudkenarDepartment of Applied Pharmacology, Kagoshima, Japan; Cardiovascular Diseases Research Center, Department of Cardiology, Heshmat Hospital, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Amaneh Mohammadi RoushandehDepartment of Applied Pharmacology, Kagoshima, Japan; Medical Biotechnology Department, Paramedicine Faculty, Guilan University of Medical Sciences, Rasht, Iran.
Kento IgarashiDepartment of Applied Pharmacology, Kagoshima, Japan.
Taisuke NagasawaDepartment of Applied Pharmacology, Kagoshima, Japan.
Yoshihiro NishitaniRestorative Dentistry and Endodontology, Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan.
Tomoaki SatoDepartment of Applied Pharmacology, Kagoshima, Japan. Electronic address: tomsato@dent.kagoshima-u.ac.jp.
Kagoshima University · JPGuilan University of Medical Sciences · IRTohoku Medical and Pharmaceutical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Most anti-cancer agents and radiotherapy exert their therapeutic effects via the production of free radicals. Ferroptosis is a recently described cell death process that is accompanied by iron-dependent lipid peroxidation. Hydrogen peroxide (H

Indexed as

AquaporinsFerroptosisMitochondriaHeLa CellsHumansHydrogen PeroxideLipid PeroxidationPermeabilityProhibitinsAquaporinsHydrogen PeroxidePHB2 protein, humanProhibitinsAquaporinFe(2+)FerroptosisHydrogen peroxideMitochondria

Identifiers

PMID33017631
PMCPMC7530583
OpenAlexW3091519160

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.