Evidence map›Paper›PMID 33017572›Full record

ReviewLife sciences2020

Nonalcoholic fatty liver disease and colorectal cancer: Correlation and missing links.

Debrup Chakraborty, Jing Wang

Open access · greenAbstract readReview
In one paragraph

Review in Life sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Subtype-specific associations of steatotic liver disease with gastric and esophageal cancers: a nationwide cohort study.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2026
    Article
  5. Article
  6. Frontiers in pharmacology · 2026
    Article
  7. Colorectal Cancer Incidence in Steatotic Liver Disease (MASLD, MetALD, and ALD).Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Debrup ChakrabortyDepartment of Cancer Biology and Genetics, James Comprehensive Cancer Center, The Ohio State University, BRT-860, 460 W 12th Ave, Columbus, OH 43210, United States of America. Electronic address: Debrup.Chakraborty@osumc.edu.
Jing WangDepartment of Cancer Biology and Genetics, James Comprehensive Cancer Center, The Ohio State University, BRT-860, 460 W 12th Ave, Columbus, OH 43210, United States of America. Electronic address: Jing.Wang@osumc.edu.
The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research Institute · US

Funding

The Functional Role of LGR5 in Colon CancerR01CA208063 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, JING · 2017 to 2022
$1.8M
The Functional Role of GRM3 in Colon CancerR01CA215389 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, JING · 2017 to 2022
$1.8M
Targeting TGFbeta/PDK4 to Overcome Drug Resistance in Colorectal CancerR01CA212241 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WANG, JING · 2017 to 2021
$1.8M
NCI NIH HHS R01 CA208063NCI NIH HHS R01 CA212241NCI NIH HHS R01 CA215389
6 · The paper itself

Abstract

Nonalcoholic fatty liver disease (NAFLD) is one of the major metabolic diseases that occur in almost one in every four global population, while colorectal cancer (CRC) is one of the leading causes of cancer related deaths in the world. Individuals with pre-existing NAFLD show a higher rate of developing CRC and liver metastasis, suggesting a causal relationship. Interestingly, both of these diseases are strongly associated with obesity, which is also a growing global health concern. In this current review, we will explore scientific findings that demonstrate the relationship between NAFLD, CRC and obesity, as well as the underlying mechanisms. We will also indicate the missing links and knowledge gaps that require more in-depth investigation.

Indexed as

AnimalsColorectal NeoplasmsGlobal HealthHumansNon-alcoholic Fatty Liver DiseaseObesityRisk FactorsCRCDormancyGut microbiotaMetastasisNAFLDObesity

Identifiers

PMID33017572
PMCPMC8128156
OpenAlexW3090248825

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.