ArticleJournal of clinical hypertension (Greenwich, Conn.)2020
Relationship between resting heart rate and incident heart failure in patients with hypertension: The Kailuan Cohort Study in China.
Article in Journal of clinical hypertension (Greenwich, Conn.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 10 citations in OpenAlex.
- The Double-High Phenotype: Synergistic Impact of Metabolic and Arterial Load on Ambulatory Blood Pressure Instability.Journal of clinical medicine · 2026Article
- Systolic blood pressure and risk of cardiovascular disease in normotensive diabetic adults: a prospective cohort study.Endocrine · 2024Article
- Effect of Presence versus Absence of Hypertension on Admission Heart Rate-Associated Cardiovascular Risk in Patients with Acute Coronary Syndrome.International journal of hypertension · 2022Article
- Association Between Heart Rate and Major Adverse Cardiovascular Events Among 9,991 Hypertentive Patients: A Multicenter Retrospective Follow-Up Study.Frontiers in cardiovascular medicine · 2021Article
- Relationship between resting heart rate and incident heart failure in patients with hypertension: The Kailuan Cohort Study in China.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
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Abstract
An elevated heart rate increases the risk of cardiovascular disease, but the relationship between resting heart rate (RHR) and the risk of heart failure (HF) in hypertensive patients is unclear. This study was performed to assess the relationship between elevated RHR and incident HF in hypertensive patients. In total, 16 286 hypertensive patients from the Kailuan cohort were enrolled and underwent three physical examinations. According to mean RHR based on quartile, the hypertensive patients were divided into four groups: Q1 (mean RHR ≤ 69 bpm), Q2 (69 bpm < mean RHR ≤ 74 bpm), Q3 (74 bpm < mean RHR ≤ 79 bpm), and Q4 (mean RHR > 79 bpm). The cumulative mortality rate was analyzed by using the Kaplan-Meier method, with comparisons among RHR quartiles. Cox proportional hazards regression models and restricted cubic spline models were established to evaluate the association between RHR and risk of incident HF. After adjustment for confounders, the hazard ratio (HR) for HF was 1.97(95% CI: 1.28-3.04, P < .001) in the fourth quartile compared to the first quartile. Each 1-standard deviation [10 (beats/min)] increase in RHR was associated with a 40% increase in the risk of incident HF. Restricted cubic spline models presented a linear relationship between RHR and incident HF. Our study suggests that elevated RHR is associated with an enhanced risk of HF in hypertensive patients.
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