SynthesisHuman brain mapping2022
Intracranial and subcortical volumes in adolescents with early-onset psychosis: A multisite mega-analysis from the ENIGMA consortium.
Synthesis in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Psychotropic medications and their interactions with subcortical brain volume in bipolar disorder: An ENIGMA mega-analysis.Molecular psychiatry · 2026Pooled it
- Intracranial and subcortical volumes in adolescents with early-onset psychosis: A multisite mega-analysis from the ENIGMA consortium.Human brain mapping · 2022Pooled it
- I Didn't Want the Psychotic Thing to Get Out to Anyone at All: Adolescents with Early Onset Psychosis Managing Stigma.Culture, medicine and psychiatry · 2024Trial
- Cerebral cortical alterations in adolescent early-onset psychosis: a surface-based morphometry mega-analysis.Molecular psychiatry · 2026Article
- Early deviations from normative brain morphology and cortical microstructure in schizophrenia spectrum disorders.Translational psychiatry · 2026Article
- An Investigation of the Correlation Between Total Intracranial Volume and Body Mass Index.Saudi medical journal · 2026Article
- Increased Brain-Age Gap in Young Adults With Psychotic Experiences.Biological psychiatry global open science · 2026Article
- Neuroanatomical Correlates of Negative Symptoms in Schizophrenia.bioRxiv : the preprint server for biology · 2025Article
- Caudate nucleus volume in medicated and unmedicated patients with early- and adult-onset schizophrenia.Scientific reports · 2024Article
- Using brain structural neuroimaging measures to predict psychosis onset for individuals at clinical high-risk.Molecular psychiatry · 2024Article
- Review
- Article
- Mapping gray and white matter volume abnormalities in early-onset psychosis: an ENIGMA multicenter voxel-based morphometry study.Molecular psychiatry · 2024Article
- Subcortical volumetric alterations in four major psychiatric disorders: a mega-analysis study of 5604 subjects and a volumetric data-driven approach for classification.Molecular psychiatry · 2023Article
- Age of Onset Moderates the Association between Total Antioxidant Capacity and Cognitive Deficits in Patients with Drug-Naïve Schizophrenia.Antioxidants (Basel, Switzerland) · 2023Article
- Genetic and Environmental Contributions to Subcortical Gray Matter Microstructure and Volume in the Developing Brain.Behavior genetics · 2023Article
- In vivo white matter microstructure in adolescents with early-onset psychosis: a multi-site mega-analysis.Molecular psychiatry · 2023Article
- A comparison of intracranial volume estimation methods and their cross-sectional and longitudinal associations with age.Human brain mapping · 2022Article
- Evidence of genetic overlap and causal relationships between blood-based biochemical traits and human cortical anatomy.Translational psychiatry · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
42 authors at 18 institutions in 8 countries.
Funding
Abstract
Early-onset psychosis disorders are serious mental disorders arising before the age of 18 years. Here, we investigate the largest neuroimaging dataset, to date, of patients with early-onset psychosis and healthy controls for differences in intracranial and subcortical brain volumes. The sample included 263 patients with early-onset psychosis (mean age: 16.4 ± 1.4 years, mean illness duration: 1.5 ± 1.4 years, 39.2% female) and 359 healthy controls (mean age: 15.9 ± 1.7 years, 45.4% female) with magnetic resonance imaging data, pooled from 11 clinical cohorts. Patients were diagnosed with early-onset schizophrenia (n = 183), affective psychosis (n = 39), or other psychotic disorders (n = 41). We used linear mixed-effects models to investigate differences in intracranial and subcortical volumes across the patient sample, diagnostic subgroup and antipsychotic medication, relative to controls. We observed significantly lower intracranial (Cohen's d = -0.39) and hippocampal (d = -0.25) volumes, and higher caudate (d = 0.25) and pallidum (d = 0.24) volumes in patients relative to controls. Intracranial volume was lower in both early-onset schizophrenia (d = -0.34) and affective psychosis (d = -0.42), and early-onset schizophrenia showed lower hippocampal (d = -0.24) and higher pallidum (d = 0.29) volumes. Patients who were currently treated with antipsychotic medication (n = 193) had significantly lower intracranial volume (d = -0.42). The findings demonstrate a similar pattern of brain alterations in early-onset psychosis as previously reported in adult psychosis, but with notably low intracranial volume. The low intracranial volume suggests disrupted neurodevelopment in adolescent early-onset psychosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.