Evidence map›Paper›PMID 33017456›Full record

Trial reportPloS one2020

Effect of a 90 g/day low-carbohydrate diet on glycaemic control, small, dense low-density lipoprotein and carotid intima-media thickness in type 2 diabetic patients: An 18-month randomised controlled trial.

Chin-Ying Chen, Wei-Sheng Huang, Hui-Chuen Chen, Chin-Hao Chang, Long-Teng Lee, Heng-Shuen Chen, Yow-Der Kang, Wei-Chu Chie, Chyi-Feng Jan, Wei-Dean Wang and 1 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 11 pooled it
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 11 syntheses or guidelines pooled it, 41 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Chin-Ying ChenDepartment of Family Medicine, National Taiwan University Hospital & National Taiwan University, Taipei, Taiwan.
Wei-Sheng HuangDepartment of Family Medicine, National Taiwan University Hospital & National Taiwan University, Taipei, Taiwan.ORCID 0000-0002-9614-1224
Hui-Chuen ChenDepartment of Dietetics, National Taiwan University Hospital & National Taiwan University, Taipei, Taiwan.
Chin-Hao ChangDepartment of Medical Research, National Taiwan University Hospital & National Taiwan University, Taipei, Taiwan.
Long-Teng LeeDepartment of Family Medicine, National Taiwan University Hospital & National Taiwan University, Taipei, Taiwan.
Heng-Shuen ChenDepartment of Family Medicine, National Taiwan University Hospital & National Taiwan University, Taipei, Taiwan.
Yow-Der KangDepartment of Family Medicine, National Taiwan University Hospital & National Taiwan University, Taipei, Taiwan.
Wei-Chu ChieDepartment of Public Health, College of Public Health, Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei, Taiwan.
Chyi-Feng JanDepartment of Family Medicine, National Taiwan University Hospital & National Taiwan University, Taipei, Taiwan.ORCID 0000-0003-2893-2187
Wei-Dean WangDepartment of Family Medicine, National Taiwan University Hospital & National Taiwan University, Taipei, Taiwan.
Jaw-Shiun TsaiDepartment of Family Medicine, National Taiwan University Hospital & National Taiwan University, Taipei, Taiwan.ORCID 0000-0002-5227-8894
National Taiwan University Hospital · TWNational Taiwan University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThis study explored the effect of a moderate (90 g/d) low-carbohydrate diet (LCD) in type 2 diabetes patients over 18 months.

methodsNinety-two poorly controlled type 2 diabetes patients aged 20-80 years with HbA1c ≥7.5% (58 mmol/mol) in the previous three months were randomly assigned to a 90 g/d LCD r traditional diabetic diet (TDD). The primary outcomes were glycaemic control status and change in medication effect score (MES). The secondary outcomes were lipid profiles, small, dense low-density lipoprotein (sdLDL), serum creatinine, microalbuminuria and carotid intima-media thickness (IMT).

resultsA total of 85 (92.4%) patients completed 18 months of the trial. At the end of the study, the LCD and TDD group consumed 88.0±29.9 g and 151.1±29.8 g of carbohydrates, respectively (p < 0.05). The 18-month mean change from baseline was statistically significant for the HbA1c (-1.6±0.3 vs. -1.0±0.3%), 2-h glucose (-94.4±20.8 vs. -18.7±25.7 mg/dl), MES (-0.42±0.32 vs. -0.05±0.24), weight (-2.8±1.8 vs. -0.7±0.7 kg), waist circumference (-5.7±2.7 vs. -1.9±1.4 cm), hip circumference (-6.1±1.8 vs. -2.9±1.7 cm) and blood pressure (-8.3±4.6/-5.0±3 vs. 1.6±0.5/2.5±1.6 mmHg) between the LCD and TDD groups (p<0.05). The 18-month mean change from baseline was not significantly different in lipid profiles, sdLDL, serum creatinine, microalbuminuria, alanine aminotransferase (ALT) and carotid IMT between the groups.

conclusionsA moderate (90 g/d) LCD showed better glycaemic control with decreasing MES, lowering blood pressure, decreasing weight, waist and hip circumference without adverse effects on lipid profiles, sdLDL, serum creatinine, microalbuminuria, ALT and carotid IMT than TDD for type 2 diabetic patients.

Indexed as

AdultAgedAged, 80 and overAtherosclerosisBlood GlucoseCarotid Intima-Media ThicknessDiabetes Mellitus, Type 2Diet, Carbohydrate-RestrictedFemaleGlycated HemoglobinHumansLipoproteins, LDLMaleMiddle AgedTreatment OutcomeYoung AdultBlood GlucoseGlycated Hemoglobinhemoglobin A1c protein, humanLipoproteins, LDL

Identifiers

PMID33017456
PMCPMC7535044
OpenAlexW3089835130

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.