Evidence map›Paper›PMID 33017437›Full record

ArticlePloS one2020

Accuracy of prenatal screening for congenital heart disease in population: A retrospective study in Southern France.

Cornélie Suard, Audrey Flori, Florent Paoli, Anderson Loundou, Virginie Fouilloux, Sabine Sigaudy, Fabrice Michel, Julie Antomarchi, Pamela Moceri, Véronique Paquis-Flucklinger and 2 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. First-trimester ultrasound detection of fetal heart anomalies: systematic review and meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2022
    Pooled it
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  12. The Impact of Prenatal Diagnosis in the Evolution of Newborns with Congenital Heart Disease.Journal of critical care medicine (Universitatea de Medicina si Farmacie din Targu-Mures) · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Cornélie SuardDepartment of Gynecology and Obstetrics, Nord Hospital, Assistance Publique des Hôpitaux de Marseille (AP-HM), Aix Marseille Université, Marseille, France.ORCID 0000-0002-6000-6995
Audrey FloriDepartment of Gynecology, Nice Teaching Hospital, Nice, France.
Florent PaoliPediatric Cardiology Service, Assistance Publique des Hopitaux de Marseille, Hôpital de la Timone Enfants, Marseille, France.
Anderson LoundouDepartment of Public Health, Medical Evaluation, Assistance Publique des Hôpitaux de Marseille, Aix- Marseille Université, Marseille France.
Virginie FouillouxDepartment of Cardiac Surgery, Children's Hospital La Timone, Assistance Publique des Hôpitaux de Marseille, Marseille, France.
Sabine SigaudyDepartment of Medical Genetics, Children's Hospital La Timone, Assistance Publique des Hopitaux de Marseille, Marseille, France.
Fabrice MichelDepartment of Pediatric Intensive Care Unit, Assistance-Publique des Hôpitaux de Marseille, Hospital La Timone, Marseille, France.ORCID 0000-0002-6972-3982
Julie AntomarchiDepartment of Obstetrics and Gynecology, Nice Teaching Hospital, Nice, France.
Pamela MoceriDepartment of cardiology, Nice Teaching Hospital, Nice, France.ORCID 0000-0002-0741-1609
Véronique Paquis-FlucklingerDepartment of Medical Genetics, National Center for Mitochondrial diseases, Nice Teaching Hospital, Nice, France.
Claude D'ErcoleDepartment of Gynecology and Obstetrics, Nord Hospital, Assistance Publique des Hôpitaux de Marseille (AP-HM), Aix Marseille Université, Marseille, France.
Florence BretelleDepartment of Gynecology and Obstetrics, Nord Hospital, Assistance Publique des Hôpitaux de Marseille (AP-HM), Aix Marseille Université, Marseille, France.
Aix-Marseille Université · FRCentre Hospitalier Universitaire de Nice · FRAssistance Publique Hôpitaux de Marseille · FRHôpital de la Timone · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Congenital heart diseases (CHDs) are the most common congenital malformations. The objective of our study was to evaluate the prenatal screening accuracy of congenital heart disease (CHD) in Southern France and to evaluate the impact of a prenatal diagnosis on pregnancies outcomes and neonatal outcomes. We performed a bicentric, retrospective observational study in the southern region over 4 years was conducted between 1 January 2014 and 31 December 2017. All foetuses and children under one year of age with CHD monitored in the UTHs (University Teaching Hospitals) in Marseille and Nice were included. CHD cases were divided into 3 groups: group 1, those with no possible options for anatomical repair; group 2, those with anatomical repair possibilities but that may require neonatal cardiologic management; and group 3, those with anatomical repair possibilities that do not require an emergency neonatal procedure. Among the 249070 deliveries during the study period, 677 CHD cases were included in the study. The overall prenatal screening rate was 71.5%. The screening rates were 97.8%, 63.6%, and 65.9% for groups 1, 2 and 3, respectively. Among group 2 CHD cases, 80% of the transpositions of the great arteries, 56% of the aortic coarctations, and 20% of the total anomalous pulmonary venous returns were detected during the prenatal period. A genetic anomaly was found in 16% of CHD cases. The overall mortality rate was 11.3% with a higher death rate in cases of prenatal screening (17.2% versus 2.1%; p < 0.001). However, when focusing only on children who died of CHD, prenatal screening did not create an impact (56.6% versus 100%, p = 0,140). Our data showed that the prenatal screening rate of CHD appears satisfactory in Southern France. Nevertheless, it could be improved for some CHD. This study did not find any benefit in terms of mortality from prenatal screening for CHD.

Indexed as

AdultFemaleFranceHeart Defects, CongenitalHumansInfant, NewbornMalePregnancyPregnancy OutcomePrenatal DiagnosisRetrospective Studies

Identifiers

PMID33017437
PMCPMC7535055
OpenAlexW3091636540

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.