Evidence map›Paper›PMID 33017395›Full record

ArticlePLoS computational biology2020

Estimation of the force of infection and infectious period of skin sores in remote Australian communities using interval-censored data.

Michael J Lydeamore, Patricia T Campbell, David J Price, Yue Wu, Adrian J Marcato, Will Cuningham, Jonathan R Carapetis, Ross M Andrews, Malcolm I McDonald, Jodie McVernon and 2 more

Open access · goldAbstract read
In one paragraph

Article in PLoS computational biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. A Mathematical Model of COVID-19 with Vaccination and Treatment.Computational and mathematical methods in medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 1 country.

Michael J LydeamoreSchool of Mathematics and Statistics, The University of Melbourne, Melbourne, Australia.ORCID 0000-0001-6515-827X
Patricia T CampbellPeter Doherty Institute for Infection and Immunity, The Royal Melbourne Hospital and The University of Melbourne, Melbourne, Australia.ORCID 0000-0003-4013-9835
David J PricePeter Doherty Institute for Infection and Immunity, The Royal Melbourne Hospital and The University of Melbourne, Melbourne, Australia.ORCID 0000-0003-0076-3123
Yue WuTelethon Kids Institute, University of Western Australia, Perth, Australia.
Adrian J MarcatoPeter Doherty Institute for Infection and Immunity, The Royal Melbourne Hospital and The University of Melbourne, Melbourne, Australia.ORCID 0000-0001-5951-6886
Will CuninghamMenzies School of Health Research, Charles Darwin University, Darwin, Australia.ORCID 0000-0001-5404-6088
Jonathan R CarapetisTelethon Kids Institute, University of Western Australia, Perth, Australia.ORCID 0000-0002-1182-9792
Ross M AndrewsMenzies School of Health Research, Charles Darwin University, Darwin, Australia.
Malcolm I McDonaldAustralian Institute of Tropical Health and Medicine, James Cook University, Cairns, Australia.ORCID 0000-0002-7225-8671
Jodie McVernonPeter Doherty Institute for Infection and Immunity, The Royal Melbourne Hospital and The University of Melbourne, Melbourne, Australia.ORCID 0000-0001-9774-1961
Steven Y C TongPeter Doherty Institute for Infection and Immunity, The Royal Melbourne Hospital and The University of Melbourne, Melbourne, Australia.ORCID 0000-0002-1368-8356
James M McCawSchool of Mathematics and Statistics, The University of Melbourne, Melbourne, Australia.ORCID 0000-0002-2452-3098
The Royal Melbourne Hospital · AUThe Kids Research Institute Australia · AUAustralian Institute of Tropical Health and Medicine · AUAustralian National University · AUCharles Darwin University · AUThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prevalence of impetigo (skin sores) remains high in remote Australian Aboriginal communities, Fiji, and other areas of socio-economic disadvantage. Skin sore infections, driven primarily in these settings by Group A Streptococcus (GAS) contribute substantially to the disease burden in these areas. Despite this, estimates for the force of infection, infectious period and basic reproductive ratio-all necessary for the construction of dynamic transmission models-have not been obtained. By utilising three datasets each containing longitudinal infection information on individuals, we estimate each of these epidemiologically important parameters. With an eye to future study design, we also quantify the optimal sampling intervals for obtaining information about these parameters. We verify the estimation method through a simulation estimation study, and test each dataset to ensure suitability to the estimation method. We find that the force of infection differs by population prevalence, and the infectious period is estimated to be between 12 and 20 days. We also find that optimal sampling interval depends on setting, with an optimal sampling interval between 9 and 11 days in a high prevalence setting, and 21 and 27 days for a lower prevalence setting. These estimates unlock future model-based investigations on the transmission dynamics of skin sores.

Indexed as

ImpetigoModels, BiologicalAustraliaComputational BiologyDatabases, FactualHumansPrevalenceStreptococcal InfectionsStreptococcus pyogenes

Identifiers

PMID33017395
PMCPMC7561265
OpenAlexW3090161145

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.