Evidence map›Paper›PMID 33017364›Full record

SynthesisCardiology in review

Elevated D-Dimer Levels Are Associated With Increased Risk of Mortality in Coronavirus Disease 2019: A Systematic Review and Meta-Analysis.

Siddharth Shah, Kuldeep Shah, Siddharth B Patel, Foram S Patel, Mohammed Osman, Poonam Velagapudi, Mohit K Turagam, Dhanunjaya Lakkireddy, Jalaj Garg

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cardiology in review. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Observational
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. COVID-19 Coagulopathy.Life (Basel, Switzerland) · 2024
    Review
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Siddharth ShahDepartment of Cardiology, State University of New York Upstate Medical University, Syracuse, NY.
Kuldeep ShahDivision of Cardiology, West Virginia University, Morgantown, WV.
Siddharth B PatelDepartment of Pulmonary, Allergy and Critical Care, University of Alabama at Birmingham, Birmingham, AL.
Foram S PatelDepartment of Infectious Diseases, University of Alabama at Birmingham, Birmingham, AL.
Mohammed OsmanDivision of Cardiology, West Virginia University, Morgantown, WV.
Poonam VelagapudiDivision of Cardiology, University of Nebraska Medical Center, Omaha, NE.
Mohit K TuragamHelmsley Electrophysiology Center, Icahn School of Medicine at Mount Sinai, New York, NY.
Dhanunjaya LakkireddyKansas City Heart Rhythm Institute and Research Foundation, Overland Park, KS.
Jalaj GargDivision of Cardiology, Cardiac Arrhythmia Service, Medical College of Wisconsin, Milwaukee, WI.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 2019 novel coronavirus, declared a pandemic, has infected 2.6 million people as of April 27, 2020, and has resulted in the death of 181,938 people. D-dimer is an important prognostic tool, is often elevated in patients with severe coronavirus disease-19 (COVID-19) infection and in those who suffered death. In this systematic review, we aimed to investigate the prognostic role of D-dimer in COVID-19-infected patients. We searched PubMed, Medline, Embase, Ovid, and Cochrane for studies reporting admission D-dimer levels in COVID-19 patients and its effect on mortality. Eighteen studies (16 retrospective and 2 prospective) with a total of 3682 patients met the inclusion criteria. The pooled weighted mean difference (WMD) demonstrated significantly elevated D-dimer levels in patients who died versus those who survived (WMD, 6.13 mg/L; 95% confidence interval [CI] 4.16-8.11; P < 0.001). Similarly, the pooled mean D-dimer levels were significantly elevated in patients with severe COVID-19 infection (WMD, 0.54 mg/L; 95% CI 0.28-0.80; P < 0.001). The risk of mortality was fourfold higher in patients with positive D-dimer versus negative D-dimer (risk ratio, 4.11; 95% CI, 2.48-6.84; P < 0.001) and the risk of developing severe disease was twofold higher in patients with positive D-dimer levels versus negative D-dimer (risk ratio, 2.04; 95% CI, 1.34-3.11; P < 0.001). Our meta-analysis demonstrates that patients with COVID-19 infection presenting with elevated D-dimer levels have an increased risk of severe disease and mortality.

Indexed as

Coronavirus InfectionsPandemicsPneumonia, ViralBetacoronavirusCOVID-19Fibrin Fibrinogen Degradation ProductsHumansMortalityPredictive Value of TestsPrognosisRisk AssessmentSARS-CoV-2Fibrin Fibrinogen Degradation Productsfibrin fragment D

Identifiers

PMID33017364
PMCPMC7437424

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.