ArticleJournal of the American Geriatrics Society2021
Low Vitamin D Levels and Risk of Incident Delirium in 351,000 Older UK Biobank Participants.
Article in Journal of the American Geriatrics Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Vitamin D and human health: evidence from Mendelian randomization studies.European journal of epidemiology · 2024Pooled it
- Micronutrient Deficiency and Its Potential Role in Delirium Onset in Older Adults: A Systematic Review.The journal of nutrition, health & aging · 2023Pooled it
- Association between vitamin D concentration and delirium in hospitalized patients: A meta-analysis.PloS one · 2023Pooled it
- Associations between polygenic risk scores for Alzheimer's disease and postoperative delirium risk.Journal of Alzheimer's disease : JAD · 2026Article
- A simulation study comparing anticholinergic drug use with polypharmacy for risk of death, dementia, and delirium in UK Biobank.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Perioperative sleep disturbances in older adults: a scoping review of epidemiology and treatment.European geriatric medicine · 2025Article
- Hypomagnesemia: An Overlooked Cause of Delirium and Cardiac Complications in an Elderly Patient.Cureus · 2025Article
- Article
- Causal relationships between delirium and Parkinson's disease: a bidirectional two-sample Mendelian randomization study.European journal of medical research · 2024Article
- Associations Between Depression Symptom Burden and Delirium Risk: A Prospective Cohort Study.Innovation in aging · 2024Article
- Associations between depression symptom burden and delirium risk: a prospective cohort study.medRxiv : the preprint server for health sciences · 2023Article
- Circadian Rest-Activity Rhythms, Delirium Risk, and Progression to Dementia.Annals of neurology · 2023Article
- Heart rate response and recovery during exercise predict future delirium risk-A prospective cohort study in middle- to older-aged adults.Journal of sport and health science · 2023Article
- Applying Mendelian randomization to appraise causality in relationships between nutrition and cancer.Cancer causes & control : CCC · 2022Article
- APOE e4 Genotypes Increase Risk of Delirium During COVID-19-Related Hospitalizations: Evidence From a Large UK Cohort.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Association of Poor Sleep Burden in Middle Age and Older Adults With Risk for Delirium During Hospitalization.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
- Association between Vitamin D Deficiency and Prognosis after Hip Fracture Surgery in Older Patients in a Dedicated Orthogeriatric Care Pathway.The journal of nutrition, health & aging · 2022Observational
- Sleep, Pain, and Cognition: Modifiable Targets for Optimal Perioperative Brain Health.Anesthesiology · 2021Review
- Analysis of the Impact of Selected Vitamins Deficiencies on the Risk of Disability in Older People.Nutrients · 2021Review
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
objectivesDelirium is common in older adults, especially following hospitalization. Because low vitamin D levels may be associated with increased delirium risk, we aimed to determine the prognostic value of blood vitamin D levels, extending our previous genetic analyses of this relationship.
designProspective cohort analysis.
settingCommunity-based cohort study of adults from 22 cities across the United Kingdom (the UK Biobank).
participantsAdults aged 60 and older by the end of follow-up in the linked hospital inpatient admissions data, up to 14 years after baseline (n = 351,320). MEASUREMENTS: At baseline, serum vitamin D (25-OH-D) levels were measured. We used time-to-event models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between vitamin D deficiency and incident hospital-diagnosed delirium, adjusted for age, sex, assessment month, assessment center, and ethnicity. We performed Mendelian randomization genetic analysis in European participants to further investigate vitamin D and delirium risk.
resultsA total of 3,634 (1.03%) participants had at least one incident hospital-diagnosed delirium episode. Vitamin D deficiency (<25 nmol/L) predicted a large incidence in delirium (HR = 2.49; 95% CI = 2.24-2.76; P = 3*10
conclusionProgressively lower vitamin D levels predicted increased risks of incident hospital-diagnosed delirium, and genetic evidence supports a shared causal pathway. Because low vitamin D levels are simple to detect and inexpensive and safe to correct, an intervention trial to confirm these results is urgently needed.
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