ArticleEuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology2021
Normal values of thermodilution-derived absolute coronary blood flow and microvascular resistance in humans.
Article in EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 72 citations in OpenAlex.
- Lumped-parameter model as a non-invasive tool to assess coronary blood flow in AAOCA patients.Scientific reports · 2023Trial
- Reproducibility of bolus versus continuous thermodilution for assessment of coronary microvascular function in patients with ANOCA.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023Trial
- Intracoronary physiological indices for coronary microvascular dysfunction: from concept to clinical application.Cardiovascular intervention and therapeutics · 2026Review
- A proposal of an echocardiography-based pathway for the diagnosis and management of angina with no obstructive coronary arteries: a state-of-the-art review: Advancing Targeted Therapy and Prognosis Through Endotype Identification.European heart journal. Imaging methods and practice · 2026Review
- Improvement of invasive microvascular indices following guideline-directed treatment of structural coronary microvascular dysfunction: a case report.European heart journal. Case reports · 2026Article
- Acute Changes in Coronary Microvascular Physiology After Supersaturated Oxygen Therapy in Anterior STEMI.JACC. Case reports · 2026Article
- Coronary Flow Reserve in Adults: Pathophysiology, Assessment Modalities, Clinical Applications, and Prognostic Significance.Medicina (Kaunas, Lithuania) · 2026Review
- Epicardial adipose tissue in coronary microvascular disease.American heart journal plus : cardiology research and practice · 2026Review
- A Statistical Shape Modeling Approach for the Derivation of a Data-Driven Geometry-Aware Lumped Arterial Stenosis Model.International journal for numerical methods in biomedical engineering · 2026Article
- Physiological Characterization of Coronary Endotypes: Potential Links with Myocardial Ischemia.Arquivos brasileiros de cardiologia · 2025Article
- A Comparison of Coupling Strategies for 1D-3D Simulations of Coronary Hemodynamics.International journal for numerical methods in biomedical engineering · 2025Article
- Invasive Endotyping of Angina Pectoris with Nonobstructive Coronary Arteries.The International journal of angiology : official publication of the International College of Angiology, Inc · 2025Review
- Invasive validation of novel 1D models for computation of coronary fractional flow reserve.Cardiovascular research · 2025Article
- Coronary microvascular disease in patients referred to coronary angiography following coronary computed tomography angiography.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Observational
- Coronary flow and resistance patterns indexed by subtended myocardial mass in coronary microvascular dysfunction.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2025Article
- Sensitivity analysis for exploring the variability and parameter landscape in virtual patient cohorts of multi-vessel coronary artery disease.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2025Article
- Evolution of Coronary Microvascular Dysfunction Prevalence over Time and Across Diagnostic Modalities in Patients with ANOCA: A Systematic Review.Journal of clinical medicine · 2025Review
- Haemodynamic response of normal aortic valves to stress using invasive, non-invasive, and computational techniques.European heart journal. Imaging methods and practice · 2025Article
- How Different is Invasive Coronary Physiology in the Left Anterior Descending Artery?Methodist DeBakey cardiovascular journal · 2025Review
- Role of optical coherence tomography in clinical management of myocardial infarction with nonobstructive coronary arteries.Journal of geriatric cardiology : JGC · 2024Article
Corrections and comments
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Authors and funding
15 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAbsolute hyperaemic coronary blood flow (Q, in mL/min) and resistance (R, in Wood units [WU]) can be measured invasively by continuous thermodilution.
aimsThe aim of this study was to assess normal reference values of Q and R.
methodsIn 177 arteries (69 patients: 25 controls, i.e., without identifiable coronary atherosclerosis; 44 patients with mild, non-obstructive atherosclerosis), thermodilution-derived hyperaemic Q and total, epicardial, and microvascular absolute resistances (Rtot, Repi, and Rmicro) were measured. In 20 controls and 29 patients, measurements were obtained in all three major coronary arteries, thus allowing calculations of Q and R for the whole heart. In 15 controls (41 vessels) and 25 patients (71 vessels), vessel-specific myocardial mass was derived from coronary computed tomography angiography.
resultsWhole heart hyperaemic Q tended to be higher in controls compared to patients (668±185 vs 582±138 mL/min, p=0.068). In the left anterior descending coronary artery (LAD), hyperaemic Q was significantly higher (293±102 mL/min versus 228±71 mL/min, p=0.004) in controls than in patients. This was driven mainly by a difference in Repi (43±23 vs 83±41 WU, p=0.048), without significant differences in Rmicro. After adjustment for vessel-specific myocardial mass, hyperaemic Q was similar in the three vascular territories (5.9±1.9, 4.9±1.7, and 5.3±2.1 mL/min/g, p=0.44, in the LAD, left circumflex and right coronary artery, respectively).
conclusionsThe present report provides reference values of absolute coronary hyperaemic Q and R. Q was homogeneously distributed in the three major myocardial territories but the large ranges of observed hyperaemic values of flow and of microvascular resistance preclude their clinical use for inter-patient comparison.
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