Evidence map›Paper›PMID 33016876›Full record

ArticleeLife2020

Structural insights into mRNA reading frame regulation by tRNA modification and slippery codon-anticodon pairing.

Eric D Hoffer, Samuel Hong, S Sunita, Tatsuya Maehigashi, Ruben L Gonzalez, Paul C Whitford, Christine M Dunham

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 43 citations in OpenAlex.

  1. NNature · 2026
    Article
  2. Review
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  10. RNA modifying enzymes shape tRNA biogenesis and function.The Journal of biological chemistry · 2024
    Review
  11. Article
  12. Review
  13. Paenilamicins from the honey bee pathogenbioRxiv : the preprint server for biology · 2024
    Article
  14. Article
  15. YfmR is a translation factor that prevents ribosome stalling and cell death in the absence of EF-P.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  16. Review
  17. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Eric D HofferDepartment of Biochemistry, Emory University School of Medicine, Atlanta, United States.
Samuel HongDepartment of Biochemistry, Emory University School of Medicine, Atlanta, United States.
S SunitaDepartment of Biochemistry, Emory University School of Medicine, Atlanta, United States.
Tatsuya MaehigashiDepartment of Biochemistry, Emory University School of Medicine, Atlanta, United States.
Ruben L GonzalezDepartment of Chemistry, Columbia University, New York, United States.ORCID 0000-0002-1344-5581
Paul C WhitfordDepartment of Physics, Northeastern University, Boston, United States.
Christine M DunhamDepartment of Biochemistry, Emory University School of Medicine, Atlanta, United States.ORCID 0000-0002-8821-688X
Emory University · USColumbia University · USNortheastern University · US

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI MALCOLM S. CAPEL · 2018 to 2026
$34.2M
Structural Studies of Ribosome RegulationR01GM093278 · NIGMS · EMORY UNIVERSITY · PI DUNHAM, CHRISTINE M · 2010 to 2022
$4.6M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Pixel Array Detector for X-ray CrystallographyS10RR029205 · NCRR · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2010 to 2010
$1.8M
Phase II SER-CAT Optimization: Acquisition of a next generation area detectorS10RR028976 · NCRR · UNIVERSITY OF GEORGIA · PI WANG, BI-CHENG · 2010 to 2010
$1.5M
The structural dynamics of translation elongation and its regulationR01GM119386 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GONZALEZ, RUBEN L · 2016 to 2019
$1.3M
Acquisition of a High Precision Micro Diffractometer to Support NIH funded Research at SER-CATS10OD027000 · OD · UNIVERSITY OF GEORGIA · PI ROSE, JOHN PATRICK · 2019 to 2019
$600k
Acquition of a microdiffractometer for SER-CATS10RR025528 · NCRR · UNIVERSITY OF GEORGIA · PI ROSE, JOHN PATRICK · 2009 to 2009
$414k
National Science Foundation MCB-1915843NCRR NIH HHS S10 RR025528NCRR NIH HHS S10 RR028976NCRR NIH HHS S10 RR029205NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R01 GM093278NIGMS NIH HHS R01 GM119386NIH HHS S10 OD021527NIH HHS S10 OD027000
6 · The paper itself

Abstract

Modifications in the tRNA anticodon loop, adjacent to the three-nucleotide anticodon, influence translation fidelity by stabilizing the tRNA to allow for accurate reading of the mRNA genetic code. One example is the N1-methylguanosine modification at guanine nucleotide 37 (m

Indexed as

Gene Expression Regulation, BacterialAnticodonCodonEscherichia coliReading FramesRibosomesRNA, MessengerRNA, TransferAnticodonCodonRNA, MessengerRNA, Transferbiochemistrychemical biologyE. colifidelityframeshiftmolecular biophysicsmRNAnear-cognateribosomestructural biologytRNA

Identifiers

PMID33016876
PMCPMC7577736
OpenAlexW3090029515

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.