Evidence map›Paper›PMID 33016509›Full record

ArticleCancer science2020

β2-AR activation promotes cleavage and nuclear translocation of Her2 and metastatic potential of cancer cells.

Dan Liu, Li Zha, Yuchen Liu, Xuan Zhao, Xiyue Xu, Shuci Liu, Wen Ma, Junnian Zheng, Ming Shi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.5field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 19 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Norepinephrine/βJournal of breast cancer · 2023
    Article
  8. Article
  9. Review
  10. Effect of chronic stress on tumorigenesis and development.Cellular and molecular life sciences : CMLS · 2022
    Review
  11. Article
  12. Article
  13. Translational cancer research · 2021
    Article
  14. Review
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Dan LiuCancer Institute, Xuzhou Medical University, Xuzhou, China.
Li ZhaCancer Institute, Xuzhou Medical University, Xuzhou, China.
Yuchen LiuCancer Institute, Xuzhou Medical University, Xuzhou, China.
Xuan ZhaoCancer Institute, Xuzhou Medical University, Xuzhou, China.
Xiyue XuCancer Institute, Xuzhou Medical University, Xuzhou, China.
Shuci LiuCancer Institute, Xuzhou Medical University, Xuzhou, China.
Wen MaCancer Institute, Xuzhou Medical University, Xuzhou, China.
Junnian ZhengCenter of Clinical Oncology, Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, China.ORCID https://orcid.org/0000-0003-0208-6410
Ming ShiCancer Institute, Xuzhou Medical University, Xuzhou, China.ORCID https://orcid.org/0000-0001-9263-6468
Xuzhou Medical College · CN

Funding

Jiangsu Natural Science Foundation BK20171161Jiangsu Province Innovation and Entrepreneurship Talents ProjectKey Research & Development Plan of Jiangsu Province BE2018634Key University Science Research Project of Jiangsu Province 17KJA320009Key Young Talents in Medicine of Jiangsu Province QNRC2016803National Natural Science Foundation of China 81773086National Natural Science Foundation of China 81773258National Natural Science Foundation of China 81972719
6 · The paper itself

Abstract

Prolonged hypersecretion of catecholamine induced by chronic stress may correlate with malignant progression of cancer. β2-adrenergic receptor (β2-AR) overexpressed in certain cancer cells may translate the signals from neuroendocrine system to malignant signals by interacting with oncoproteins, such as Her2. In the present study, we demonstrate that catecholamine stimulation activates the expression and proteolytic activity of ADAM10 by modulating the expression of miR-199a-5p and SIRT1 and also confirm that catecholamine induction triggers the activities of γ-secretase, leading to shedding of Her2 extracellular domain (ECD) by ADAM10 and subsequent intramembranous cleavage of Her2 intracellular domain (ICD) by presenilin-dependent γ-secretase, nuclear translocation of Her2 ICD, and enhanced transcription of tumor metastasis-associated gene COX-2. Chronic stimulation of catecholamine strongly promotes the invasive activities of cancer cells in vitro and spontaneous tumor lung metastasis in mice. Furthermore, nuclear localization of Her2 was significantly correlated with overexpression of β2-AR in human breast cancer tissues, indicating that catecholamine-induced β2-AR activation plays decisive roles in tumor metastasis. Our data also reveal that an unknown mechanism by which the regulated intramembrane proteolysis (RIP) initiated by β2-AR-mediated signaling controls a novel Her2-mediated signaling transduction.

Indexed as

Neoplasm MetastasisADAM10 ProteinAdrenergic beta-2 Receptor AgonistsAmyloid Precursor Protein SecretasesAnimalsBreast NeoplasmsCatecholaminesCell Line, TumorCell NucleusCyclooxygenase 2Erb-b2 Receptor Tyrosine KinasesFemaleHumansIsoproterenolLung NeoplasmsMCF-7 CellsADAM10 ProteinAdrenergic beta-2 Receptor AgonistsAmyloid Precursor Protein SecretasesCatecholaminesCyclooxygenase 2ERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesIsoproterenolMicroRNAsmirn199 microRNA, humanReceptors, Adrenergic, beta-2SIRT1 protein, humanSirtuin 1a disintegrin and metalloprotease 10Her2metastasisβ2-adrenergic receptorγ-secretase

Identifiers

PMID33016509
PMCPMC7734010
OpenAlexW3090616703

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.