Evidence map›Paper›PMID 33016101›Full record

ArticleCirculation2020

Forty-Year Shifting Distribution of Systolic Blood Pressure With Population Hypertension Treatment and Control.

Daniel T Lackland, Virginia J Howard, Mary Cushman, Suzanne Oparil, Brett Kissela, Monika M Safford, Dawn O Kleindorfer, Leslie A McClure, George Howard

Abstract read
In one paragraph

Article in Circulation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Black-white Differences in Left Ventricular Hypertrophy Rates Among Young Adults with Ischemic Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniel T LacklandDepartment of Neurology, Medical University of South Carolina, Charleston (D.T.L.).
Virginia J HowardDepartment of Epidemiology (V.J.H.), University of Alabama at Birmingham.
Mary CushmanDepartment of Medicine, Larner College of Medicine at the University of Vermont, Burlington (M.C.).
Suzanne OparilDepartment of Medicine (S.O.), University of Alabama at Birmingham.
Brett KisselaDepartment of Neurology, University of Cincinnati, OH (B.K.).
Monika M SaffordDepartment of Internal Medicine, Weill Cornell Medical Center, New York (M.M.S.).
Dawn O KleindorferDepartment of Neurology, University of Michigan Medical School, Ann Arbor (D.O.K.).
Leslie A McClureDepartment of Biostatistics and Epidemiology, Drexel University, Philadelphia, PA (L.A.M.).
George HowardDepartment of Biostatistics (G.H.), School of Public Health, University of Alabama at Birmingham.

Funding

VCID and Stroke in a Bi-racial National CohortU01NS041588 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI CUSHMAN, MARY, HOWARD, GEORGE · 2002 to 2022
$96.0M
University of Alabama at Birmingham's Diabetes Research CenterP30DK079626 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Kirk Michael Habegger · 2013 to 2026
$19.5M
Black Pooling ProjectR01HL072377 · NHLBI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LACKLAND, DANIEL T · 2003 to 2005
$657k
NHLBI NIH HHS R01 HL072377NIDDK NIH HHS P30 DK079626NINDS NIH HHS U01 NS041588
6 · The paper itself

Abstract

backgroundHypertension awareness, treatment, and control programs were initiated in the United States during the 1960s and 1970s. Whereas blood pressure (BP) control in the population and subsequent reduced hypertension-related disease risks have improved since the implementation of these interventions, it is unclear whether these BP changes can be generalized to diverse and high-risk populations. This report describes the 4-decade change in BP levels for the population in a high disease risk southeastern region of the United States. The objective is to determine the magnitude of the shift in systolic BP (SBP) among Blacks and Whites from the Southeast between 1960 and 2005 with the assessment of the unique population cohorts.

methodsA multicohort study design compared BPs from the CHS (Charleston Heart Study) and ECHS (Evans County Heart Study) in 1960 and the REGARDS study (Reasons for Geographic and Racial Differences in Stroke) 4 decades later. The analyses included participants ≥45 years of age from CHS (n=1323), ECHS (n=1842), and REGARDS (n=6294) with the main outcome of SBP distribution.

resultsAmong Whites 45 to 54 years of age, the median SBP was 18 mm Hg (95% CI, 16-21 mm Hg) lower in 2005 than 1960. The median shift was a 45 mm Hg (95% CI, 37-51 mm Hg) decline for those ≥75 years of age. The shift was larger for Blacks, with median declines of 38 mm Hg (95% CI, 32-40 mm Hg) at 45 to 54 years of age and 50 mm Hg (95% CI, 33-60 mm Hg) for ages ≥75 years. The 95th percentile of SBP decreased 60 mm Hg for Whites and 70 mm Hg for Blacks.

conclusionsThe results of the current analyses of the unique cohorts in the Southeast confirm the improvements in population SBP levels since 1960. This assessment provides new evidence of improvement in SBP, suggesting that strategies and programs implemented to improve hypertension treatment and control have been extraordinarily successful for both Blacks and Whites residing in a high-risk region of the United States. Severe BP elevations commonly observed in the 1960s have been nearly eliminated, with the current 75th percentile of BP generally less than the 25th percentile of BP in 1960.

Indexed as

AgedBlood PressureCase-Control StudiesFemaleHumansHypertensionMaleMiddle AgedRisk FactorsTime FactorsUnited Statesblood pressurehypertensionpopulation

Identifiers

PMID33016101
PMCPMC7578084

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.